Home / NFL / Washington Commanders at San Francisco 49ers Predictions & Picks – Unbeaten 49ers To Cover In Monday NFL Win
Washington Commanders at San Francisco 49ers Predictions & Picks – Unbeaten 49ers To Cover In Monday NFL Win
- San Francisco favored to extend perfect 5-0 start and cover spread
- Washington yet to win on the road; recently tied after late-game management blunder
- 49ers lead the all-time series 23-12-1 and won the last matchup 27-10

Washington Commanders at San Francisco 49ers Predictions & Picks
San Francisco are tipped to cover as they keep their perfect record intact.
The 49ers continue to deal with injuries, but they are off to a flying start and the offense is rolling after five weeks of the season.
Washington, on the other hand, just contrived to tie a game with the Giants that was theirs for the taking, and they head to Santa Clara without a win on the road this season.
- San Francisco 49ers boast a 5-0 record
- San Francisco 49ers are 4-1-0 ATS so far this season
- Washington Commanders are 0-2 on the road
- The Over has cashed in 7 of the 10 games involving either team
Head To Head
- San Francisco 49ers lead the all-time series 23-12-1
- San Francisco 49ers won 27-10 when the two teams last met in December 2023
Washington Commanders Form
Washington head to California on the back on an embarrassing finish to the game against New York that left them still seeking a second win.
The Commanders opened the season with back-to-back road games against division opponents, and came up short in both of them.
They were beaten 24-22 in Philadelphia, before heading to Dallas for a 37-20 defeat at the hands of the Cowboys.
Washington finally got off the mark with a 33-31 upset of Seattle at home, but quickly returned to losing ways as they fell 30-13 to Indianapolis.
The Commanders appeared poised to rebound from that loss when they marched into field goal range in overtime against the Giants last Sunday, but they made a complete mess of their clock management to allow time to expire with the teams locked at 20-20.
San Francisco 49ers Form
San Francisco enter this matchup having maintained their perfect record with another big division win last weekend.
The 49ers kicked off their campaign in Australia, where they beat NFC West rivals, and Super Bowl favourites, the Los Angeles Rams, 27-7.
They backed that up in their home opener as they beat Miami 35-13, and they then notched another division win a week later as they downed Arizona 36-30.
San Francisco made it four-in-a-row with a 24-14 victory over Denver, setting themselves up for a big trip to face defending champions Seattle last weekend.
The 49ers ran out winners in that big NFC West clash too, as they edged the Seahawks 32-29.
Verdict
Washington’s overtime screw-up will go down in history as one of the biggest mistakes in NFL history.
It did not cost Dan Quinn his job, but this in-form San Francisco group can edge the Commanders head coach closer to the exit door on Monday night.
It did not cost Dan Quinn his job, but this in-form San Francisco group can edge the Commanders head coach closer to the exit door on Monday night.
Leigh Copson
Sports Editor • 25+ Years Experience, US & Combat Sports Specialist
US sports writer covering the NFL, NBA, NHL, boxing and MMA, with previews, predictions and betting tips across the major American leagues.
During his career at the Press Association and online sports sites including FreeTips and ExpertPicks.com, he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final.
He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.