Home / NFL / Arizona Cardinals at Los Angeles Rams Predictions & Picks – Rams To Rebound With Big NFL Division Win
Arizona Cardinals at Los Angeles Rams Predictions & Picks – Rams To Rebound With Big NFL Division Win
- Rams predicted to beat Cardinals and cover -12.5 spread
- Arizona enters game on a four-game losing streak with defensive struggles
- Los Angeles has dominated recent matchups, winning 8 of last 10 meetings

Arizona Cardinals at Los Angeles Rams Predictions & Picks
Los Angeles are tipped to cover as they bounce back from the overtime loss to Buffalo.
The Rams have struggled to live up to pre-season expectations, but Matthew Stafford and this offense is unlikely to have many issues racking up points on a bad Cardinals defense.
- Los Angeles Rams are 2-0-0 ATS in their 2 wins
- Los Angeles Rams are 8-2 in the last 10 meetings
- Los Angeles Rams are 7-3-0 ATS in the last 10 meetings
- The Over has cashed in each of Los Angeles’ last 3 games
Head To Head
- Los Angeles Rams lead the all-time series 55-41-2
- Los Angeles Rams won 37-20 when the two teams last met in January 2026
Arizona Cardinals Form
Arizona head to Los Angeles having now lost four consecutive games to fall to 1-4 this season.
The Cardinals opened with a 26-14 win at the Los Angeles Chargers, but they have not tasted victory since then.
They dropped their home opener against division rivals Seattle, 31-7, and then lost to another NFC West foe on the road, San Francisco, 36-30.
Arizona went back out on the road the following week too, and suffered a 36-24 defeat at the hands of the New York Giants.
The Cardinals’ losing run then reached four games a week ago, as they were blown out at home by Detroit, 45-21.
Los Angeles Rams Form
Los Angeles go into this matchup on the back of an overtime defeat at home – their third defeat of the season.
The Rams came into the season as the favourites to win the Super Bowl, but they have underwhelmed while dealing with a bunch of injuries.
They were beaten 27-7 by San Francisco in the season-opener in Australia, only to rebound a week later with a 28-6 win over the New York Giants.
Los Angeles failed to build on that as they lost 30-26 in Denver, but responded quickly to a loss as they beat Philadelphia 24-20 on the road.
The Rams were again unable to back up a win though, as they lost 37-34 in overtime when they hosted Buffalo last Monday night.
Verdict
Los Angeles are yet to live up to the lofty pre-season expectations, but this is a good opportunity for them to get back on track.
Arizona’s defense has been a mess through five weeks, and the Rams can light them up here to win the game and cover the spread.
Arizona’s defense has been a mess through five weeks, and the Rams can light them up here to win the game and cover the spread.
Leigh Copson
Sports Editor • 25+ Years Experience, US & Combat Sports Specialist
US sports writer covering the NFL, NBA, NHL, boxing and MMA, with previews, predictions and betting tips across the major American leagues.
During his career at the Press Association and online sports sites including FreeTips and ExpertPicks.com, he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final.
He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.