2026 NFL Draft Odds – Fernando Mendoza Overwhelming Favorite To Be Number 1 Pick After Indiana Success
21 Jan 2026Read More
New Orleans Saints at San Francisco 49ers Preview & Picks – In-Form 49ers To Cover In NFL Win
- New Orleans Saints at San Francisco 49ers picks for Sunday, November 27
- Matchup gets underway at 16:25 ET at Levi’s Stadium
- Preview, stats & head-to-head
- New Orleans Saints at San Francisco 49ers Preview & Picks
- Head To Head
- New Orleans Saints Form
- San Francisco 49ers Form
- New Orleans Saints at San Francisco 49ers FAQs
New Orleans Saints at San Francisco 49ers Preview & Picks
New Orleans Saints at San Francisco 49ers Preview & Picks
San Francisco are tipped to cover in a home win.
The 49ers offense is firing and the defense has been shutting down opposition offenses recently.
They now face a hit-and-miss New Orleans team who are yet to cover on the road this season.
- San Francisco are 6-2-0 ATS in their last 8 home games
- San Francisco are 10-2-0 ATS in their last 12 games vs NFC teams
- New Orleans Saints are 0-4-0 ATS on the road this season
- The Over has cashed in 4 of San Francisco’s last 6 games
- The Over has hit in 5 of San Francisco’s last 8 games
Head To Head
- San Francisco 49ers lead the all-time series 49-27-2
- New Orleans Saints won 27-13 when the teams last met in November 2020
New Orleans Saints Form
New Orleans go into this game with a 4-7 record but still in the hunt in the wide open NFC South.
The Saints opened the season with a 27-26 win in Atlanta, only to see their form quickly tail off.
They lost 20-10 at home to Tampa Bay and 22-14 in Carolina, before heading to London for a 28-25 defeat to Minnesota.
New Orleans stopped the rot with a 39-32 upset of Seattle, but immediately returned to losing ways with a 30-26 defeat to Cincinnati and a 42-34 loss in Arizona.
A 24-0 shutout win against Las Vegas did not kick-start their season either, as they then lost 27-13 to Baltimore and 20-10 in Pittsburgh.
The Saints to go into this game on the back of a victory though, having beaten the Los Angeles Rams 27-20 last weekend.
San Francisco 49ers Form
San Francisco return home looking to extend a three-game win streak after Monday’s win in Mexico.
The 49ers went 1-1 through the first two games as they bounced back from a shock 19-10 defeat in Chicago with a 27-7 win against Seattle.
They tripped up again a week later with a 11-10 defeat in Denver, but responded to that with a couple of wins.
San Francisco downed the Los Angeles Rams 24-9 and Carolina 37-15, only to then lose their next two games to fall back below .500.
The Niners suffered a surprise 28-14 defeat in Atlanta before losing 44-23 at home to Kansas City, but they at least stopped the rot before the bye week with a 31-14 win at the Rams.
They have built on that win since the bye, backing up a 22-16 win at home to the Los Angeles Chargers with a 38-10 win against the Cardinals in Mexico.
New Orleans Saints at San Francisco 49ers FAQs
Where can I watch the New Orleans Saints at San Francisco 49ers live stream?
You can watch the New Orleans Saints at San Francisco 49ers live stream at Stake.
What is the New Orleans Saints at San Francisco 49ers start time?
The New Orleans Saints at San Francisco 49ers game is set to start at 16:25 ET.
Verdict
San Francisco are the team in better form and are delivering on both sides of the football.
They are backed to extend their win streak and cover at the expense of the ‘travel sick’ Saints.
They are backed to extend their win streak and cover at the expense of the ‘travel sick’ Saints.
San Francisco -9.5
Spread
@-111.11 - 4 Units
25 SC no deposit & 250,000 GC
Use promo code NEWBONUS
Get 25 Stake Cash & 250,000 Gold Coins when you sign up with code NEWBONUS at Stake.us. USA only. Excludes certain States including NY,NV,ID, KY,WA. 18+ only. Terms and Conditions apply.
Over 43.0
Total Points
@-111.11 - 2 Units
25 SC no deposit & 250,000 GC
Use promo code NEWBONUS
Get 25 Stake Cash & 250,000 Gold Coins when you sign up with code NEWBONUS at Stake.us. USA only. Excludes certain States including NY,NV,ID, KY,WA. 18+ only. Terms and Conditions apply.
See also
- Pittsburgh Steelers at Indianapolis Colts Live Stream – How To Watch Live Online With Stake
- Green Bay Packers at Philadelphia Eagles Live Stream – How To Watch Live Online With Stake
- Pittsburgh Steelers at Indianapolis Colts Preview & Picks – NFL Monday Game To Be Low-Scoring
- Green Bay Packers at Philadelphia Eagles Preview & Picks – Eagles To Cover In NFL Sunday Showdown
- New England Patriots at Minnesota Vikings – Get Double Winnings With Stake’s NFL Thanksgiving Day Offer
- New York Giants at Dallas Cowboys – Get Double Winnings With Stake’s NFL Thanksgiving Day Offer
- Buffalo Bills at Detroit Lions – Get Double Winnings With Stake’s NFL Thanksgiving Day Offer
- Cincinnati Bengals at Tennessee Titans Preview & Picks – Titans To Cover As Home NFL Underdog
- New England Patriots at Minnesota Vikings Live Stream – How To Watch Live Online With Stake
- New England Patriots at Minnesota Vikings Preview & Picks – Vikings To Hit Back In NFL Thursday Game
- Buffalo Bills at Detroit Lions Preview & Picks – Buffalo To Cover In NFL Thanksgiving Clash
- New York Giants at Dallas Cowboys Preview & Picks – Dallas To Cover In Crucial NFL Matchup
Upcoming Events
08 April 2026
Daniil Medvedev vs Matteo Berrettini Tennis
Daniil Medvedev vs Matteo Berrettini Betting Picks & Live Stream – Early Advantage with Berrettini in Monte Carlo
Cristian Garin vs Alexander Zverev Tennis
Cristian Garin vs Alexander Zverev Betting Picks & Live Stream – Garin to Keep It Competitive in Monte Carlo
Felix Auger Aliassime vs Marin Cilic Tennis
Felix Auger-Aliassime vs Marin Cilic Betting Picks & Live Stream – FAA to Edge Tight Match in Monte Carlo
Corentin Moutet vs Casper Ruud Tennis
Corentin Moutet vs Casper Ruud Betting Picks & Live Stream – Ruud to Assert His Clay Advantage in Monte Carlo
Lorenzo Musetti vs Valentin Vacherot Tennis
Lorenzo Musetti vs Valentin Vacherot Betting Picks & Live Stream – Vacherot to Seize Opportunity in Monte Carlo
09 April 2026
11 April 2026
Tyson Fury vs Arslanbek Makhmudov Boxing
Tyson Fury vs Arslanbek Makhmudov Predictions & Picks – Fury To KO Makhmudov In Comeback Fight
12 April 2026
23 April 2026
17 May 2026
Nate Diaz vs Mike Perry UFC
Nate Diaz vs Mike Perry Predictions & Picks – Diaz To Upset Perry On Rousey-Carano Netflix Card
Ronda Rousey vs Gina Carano UFC
Ronda Rousey vs Gina Carano Preview & Picks – Rousey To Tap Out Carano In Netflix Super-Fight
30 June 2026
NHL 2025/26 Betting Specials Ice Hockey
NHL Daily Pick ‘Em Game – Win Cash Prizes, Trips To NHL Games & More With BET99's Free-To-Play Competition
20 September 2026
Floyd Mayweather Jr vs Manny Pacquiao 2 Boxing
Floyd Mayweather Jr vs Manny Pacquiao 2 Preview & Picks – Mayweather To Repeat 2015 Victory
31 October 2026
2026 MLB Betting Specials Baseball
MLB Baseball Offer – Money Back If Your Team Leads At Start Of 9th Innings But Loses
Poker EventsStarts in
Daniil Medvedev vs Matteo Berrettini
Cristian Garin vs Alexander Zverev
Felix Auger Aliassime vs Marin Cilic
Corentin Moutet vs Casper Ruud
Lorenzo Musetti vs Valentin Vacherot
The Masters
Tyson Fury vs Arslanbek Makhmudov
Jiri Prochazka vs Carlos Ulberg
2026 NFL Draft
Nate Diaz vs Mike Perry
Ronda Rousey vs Gina Carano
NHL 2025/26 Betting Specials
Latest News
-
Latest Odds -
NFL OddsSuper Bowl LXI Odds – Seattle Seahawks Favored For Back-To-Back NFL Crowns10 Feb 2026Read More
-
Back SeahawksSeattle Seahawks vs New England Patriots Preview & Picks – Seahawks To Win Super Bowl LX05 Feb 2026Read More
-
Super Bowl TipsSeattle Seahawks vs New England Patriots MVP Preview & Picks – Who Will Be Named Super Bowl LX MVP?05 Feb 2026Read More
-
NFL TipsSeattle Seahawks vs New England Patriots Preview & Picks – Who Will Score 1st Touchdown Of Super Bowl LX?05 Feb 2026Read More
