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Home / MLB / Chicago White Sox at Cleveland Guardians Predictions & Picks – Underdog Sox To Win MLB Clash

Chicago White Sox at Cleveland Guardians Predictions & Picks – Underdog Sox To Win MLB Clash

Quick Read

  • Chicago White Sox at Cleveland Guardians picks for Monday, September 14
  • Game is taking place at Progressive Field
  • Preview, predictions, stats & form
Leigh Copson
Written by Leigh Copson
Sports Editor25+ Years Experience, US & Combat Sports Specialist
Updated: Sep 14, 2026
mlb white sox guardians
Our TipStrong confidence
Stake.us

Moneyline

Chicago Win

Odds

120.00

Place Bet
Stake.us

Total Runs

Over 7.0

Odds

-104.17

Place Bet

Chicago White Sox at Cleveland Guardians Predictions & Picks

Chicago are tipped to spring an upset in the opening game of this crucial AL Central series.

The White Sox have a slight lead in the season series, and the Guardians possess one of the worst home records in the league.

  • Chicago White Sox are 6-4 in the previous 10 meetings this season
  • Cleveland Guardians are 8-11 in their last 19 home games
  • The Over has cashed in 3 of the previous 4 meetings

Head To Head

  • Cleveland Guardians lead the all-time series 1139-1137-17
  • Chicago White Sox won 5-3 when the two teams last met on August 9

Chicago White Sox Form

Chicago head to Cleveland on a bad run of form, having just suffered their eighth defeat in their last 11 games.

DateOppositionW/LScore
Sep-03 at Houston Astros L 2-6
Sep-04 vs Minnesota Twins W 4-1
Sep-05 vs Minnesota Twins L 4-6
Sep-06 vs Minnesota Twins W 10-1
Sep-08 vs Pittsburgh Pirates L 3-9
Sep-09 vs Pittsburgh Pirates L 2-4
Sep-10 vs Pittsburgh Pirates L 0-2
Sep-11 at St Louis Cardinals L 3-7
Sep-12 at St Louis Cardinals W 6-5
Sep-13 at St Louis Cardinals L 1-3

Cleveland Guardians Form

Cleveland enter this series having won six of their last 10 games, but having not won back-to-back games since September 4.

DateOppositionW/LScore
Sep-04 vs Detroit Tigers W 7-6 W/O
Sep-04 vs Detroit Tigers W 4-3 W/O
Sep-05 vs Detroit Tigers L 0-6
Sep-06 vs Detroit Tigers W 3-2 W/O
Sep-07 at Baltimore Orioles L 4-6
Sep-08 at Baltimore Orioles W 9-5
Sep-09 at Baltimore Orioles L 5-9
Sep-11 at Minnesota Twins W 5-2
Sep-12 at Minnesota Twins L 3-4
Sep-13 at Minnesota Twins W 9-2

Starting Pitchers

PlayerTeamRecordERAStrikeoutsInnings
Sean Newcomb Chicago White Sox 2-4 2.77 78 84.1
Gavin Williams Cleveland Guardians 13-7 3.78 228 169.0

Verdict

Our Verdict
Chicago’s current form is underwhelming, but they have had a slight edge over the Guardians this season, and Cleveland have hardly been great at home.

Give us the plus-money in this matchup.

Stake.us
Top Pick

Chicago Win

at Stake.us

Stake.us

Over 7.0

at Stake.us

-104.17Visit Site
Leigh Copson
Leigh Copson

Sports Editor25+ Years Experience, US & Combat Sports Specialist

During his career he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final. He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.


Follow more of Leigh's work on Muckrack.

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