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Home / MLB / Chicago White Sox at Cleveland Guardians Predictions & Picks – Underdog Sox To Win Again In MLB

Chicago White Sox at Cleveland Guardians Predictions & Picks – Underdog Sox To Win Again In MLB

Quick Read

  • Chicago White Sox at Cleveland Guardians picks for Tuesday, September 15
  • Game is taking place at Progressive Field
  • Preview, predictions, stats & form
Leigh Copson
Written by Leigh Copson
Sports Editor25+ Years Experience, US & Combat Sports Specialist
Updated: Sep 15, 2026
Chicago White Sox at Cleveland Guardians Predictions & Picks – Underdog Sox To Win Again In MLB
Our TipStrong confidence
Stake.us

Moneyline

Chicago Win

Odds

105.00

Place Bet
Stake.us

Total Runs

Over 8.5

Odds

-116.28

Place Bet

Chicago White Sox at Cleveland Guardians Predictions & Picks

Chicago are tipped to win as an underdog for the second straight day in Cleveland.

Davis Martin has been in improved form for the White Sox recently, while the visitors can build on last night’s strong offense showing Foster Griffin, who has struggled since joining the Guardians.

  • Chicago White Sox are 7-4 in the previous 11 meetings this season
  • Cleveland Guardians are 8-12 in their last 20 home games
  • Davis Martin has a 5.94 ERA since joining Cleveland Guardians
  • The Over has cashed in 4 of the previous 5 meetings

Head To Head

  • Cleveland Guardians lead the all-time series 1139-1138-17
  • Chicago White Sox won 7-3 when the two teams last met on September 14

Chicago White Sox Form

Chicago go into the second game of this series having lost six of their last 10, but having beaten the Guardians 7-3 in Monday's series opener.

DateOppositionW/LScore
Sep-04 vs Minnesota Twins W 4-1
Sep-05 vs Minnesota Twins L 4-6
Sep-06 vs Minnesota Twins W 10-1
Sep-08 vs Pittsburgh Pirates L 3-9
Sep-09 vs Pittsburgh Pirates L 2-4
Sep-10 vs Pittsburgh Pirates L 0-2
Sep-11 at St Louis Cardinals L 3-7
Sep-12 at St Louis Cardinals W 6-5
Sep-13 at St Louis Cardinals L 1-3
Sep-14 at Cleveland Guardians W 7-3

Cleveland Guardians Form

Cleveland enter this matchup having split their previous 10 games overall, and having not won consecutive games since September 4.

DateOppositionW/LScore
Sep-04 vs Detroit Tigers W 4-3 W/O
Sep-05 vs Detroit Tigers L 0-6
Sep-06 vs Detroit Tigers W 3-2 W/O
Sep-07 at Baltimore Orioles L 4-6
Sep-08 at Baltimore Orioles W 9-5
Sep-09 at Baltimore Orioles L 5-9
Sep-11 at Minnesota Twins W 5-2
Sep-12 at Minnesota Twins L 3-4
Sep-13 at Minnesota Twins W 9-2
Sep-14 vs Chicago White Sox L 3--7

Starting Pitchers

PlayerTeamRecordERAStrikeoutsInnings
Davis Martin Chicago White Sox 9-7 4.05 115 135.2
Foster Griffin Cleveland Guardians 15-5 3.65 146 162.2

Verdict

Our Verdict
Chicago delivered as an underdog on Monday and we like their chances of repeating here.

Griffin has had a tough time since making the move from Washington to Cleveland, making this a good opportunity for the White Sox bats to back up yesterday’s seven-run showing.

Stake.us
Top Pick

Chicago Win

at Stake.us

Stake.us

Over 8.5

at Stake.us

-116.28Visit Site
Leigh Copson
Leigh Copson

Sports Editor25+ Years Experience, US & Combat Sports Specialist

During his career he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final. He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.


Follow more of Leigh's work on Muckrack.

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