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Home / MLB / Minnesota Twins at San Francisco Giants Predictions & Picks – Twins To Earn 3rd Win On MLB Road Trip

Minnesota Twins at San Francisco Giants Predictions & Picks – Twins To Earn 3rd Win On MLB Road Trip

Quick Read

  • Minnesota Twins are favored due to Giants' injuries and poor form
  • Both teams' starting pitchers have high ERAs, suggesting a high-scoring game
  • Moneyline pick: Twins to win; Total Runs pick: Over 8.5
Leigh Copson
Written by Leigh Copson
Sports Editor25+ Years Experience, US & Combat Sports Specialist
Updated: Sep 21, 2026
mlb twins giants
Our TipStrong confidence
Stake.us

Moneyline

Minnesota Win

Odds

-125.00

Place Bet
Stake.us

Total Runs

Over 8.5

Odds

-105.26

Place Bet

Minnesota Twins at San Francisco Giants Predictions & Picks

Minnesota are tipped to open this series with a victory.

The Twins picked up a couple of wins in Los Angeles last week, and they can take advantage of a Giants team dealing with a bunch of injuries at this time.

  • Minnesota Twins have won 2 of their 4 games on this road trip
  • San Francisco Giants are 4-5 in their previous 9 home games
  • Minnesota Twins won all 3 meetings with San Francisco last season
  • The two starting pitchers have a combined ERA of 9.28

Head To Head

  • San Francisco Giants lead the all-time series 20-19
  • Minnesota Twins won 7-6 when the two teams last met in May 2025

Minnesota Twins Form

Minnesota head to the Bay Area having lost six of their previous 10 games, and having split their first four games on this road trip.

DateOppositionW/LScore
Sep-11 vs Cleveland Guardians L 2-5
Sep-12 vs Cleveland Guardians W 4-3
Sep-13 vs Cleveland Guardians L 2-9
Sep-14 vs New York Yankees L 3-8
Sep-15 vs New York Yankees L 1-8
Sep-16 vs New York Yankees W 5-4 W/O
Sep-17 at Los Angeles Angels L 4-5 W/O
Sep-18 at Los Angeles Angels W 3-0
Sep-19 at Los Angeles Angels L 5-6 W/O
Sep-20 at Los Angeles Angels W 8-0

San Francisco Giants Form

San Francisco go into their penultimate series of the season in miserable form, having lost seven of their last nine games and each of the last three.

DateOppositionW/LScore
Sep-09 vs St Louis Cardinals W 7-6
Sep-11 vs San Diego Padres L 5-7
Sep-12 vs San Diego Padres L 6-7
Sep-13 vs San Diego Padres L 4-6
Sep-14 at St Louis Cardinals L 1-2
Sep-15 at St Louis Cardinals W 10-3
Sep-16 at St Louis Cardinals W 6-5
Sep-18 at Los Angeles Dodgers L 2-8
Sep-19 at Los Angeles Dodgers L 4-10
Sep-20 at Los Angeles Dodgers L 1-3

Starting Pitchers

PlayerTeamRecordERAStrikeoutsInnings
Zebby Matthews Minnesota Twins 9-10 4.74 107 125.1
Blade Tidwell San Francisco Giants 1-2 4.56 42 53.1

Verdict

Neither team is playoff bound, but both will want to at least finish the season with some positive outings.

This could be a good outing for the Twins, who get to face a hittable pitcher and an injury-hit Giants team.

Stake.us
Top Pick

Minnesota Win

at Stake.us

-125.00Visit Site
Stake.us

Over 8.5

at Stake.us

-105.26Visit Site
Leigh Copson
Leigh Copson

Sports Editor25+ Years Experience, US & Combat Sports Specialist

Leigh Copson is the editor of expert picks and provides daily picks for the NFL, NBA, NHL, MLB boxing and MMA. He provides analysis of the big events across major American leagues every day.


He started out with the Press Association before moving online and working for ExpertPicks.com, FreeTips.com and other sports news and betting sites. 

He has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final and has covered almost every major boxing match and UFC fight card during this time.

Follow more of Leigh's work on Muckrack and connect with him on LinkedIn.


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