San Francisco 49ers at Arizona Cardinals Preview & Picks
San Francisco are backed to cover in Mexico.
The 49ers’ offense is a work in progress but is coming up against one of the NFL’s worst defenses.
And on the opposite side of the football, the Niners defense is getting back to their dominant best.
- San Francisco are 5-0-0 ATS in their last 5 NFC West games
- San Francisco are 9-2-0 ATS in their last 11 conference games
- Arizona are 1-6-0 ATS in their last 7 NFC West games
- The Under has cashed in 13 of San Francisco’s last 17 games
Head To Head
- San Francisco 49ers lead the all-time series 32-29
- Arizona Cardinals won 31-17 when the teams last met in November 2021
San Francisco 49ers Form
San Francisco head to Mexico having won either side of the bye week to improve to 5-4.
The 49ers stumbled out of the blocks as they lost two of their first three games of the 2022 season.
They rebounded with back-to-back wins, beating the LA Rams 24-9 and Carolina 37-15, but their momentum then stalled.
San Francisco were upset 28-14 in Atlanta before returning home for a 44-23 defeat to Kansas City.
The 49ers stopped the rot before the bye week though, dominating the Rams in a 31-14 victory.
They then backed up that victory when they returned to action last week, beating the LA Chargers 22-16 at home.
Arizona Cardinals Form
This is a massive matchup for an Arizona team who have gone 4-6 through the first 10 weeks.
The Cardinals went 2-2 through their first four games, losing at home to Kansas City and the LA Rams while beating Las Vegas and Carolina on the road.
The offense then stalled as they lost back-to-back games against Philadelphia (20-17) and Seattle (19-9).
Arizona bounced back with a 42-34 shootout win at home to New Orleans, but were unable to build on that.
The Cardinals were beaten 34-26 at Minnesota before returning home to suffer a 31-21 defeat to Seattle.
They did keep their season alive last weekend though, beating the Rams 27-17 on the road with backup QB Colt McCoy at the controls.
San Francisco 49ers at Arizona Cardinals FAQs
Where can I watch the San Francisco 49ers at Arizona Cardinals live stream?
You can watch the San Francisco 49ers at Arizona Cardinals live stream at Stake.
What is the San Francisco 49ers at Arizona Cardinals start time?
The San Francisco 49ers at Arizona Cardinals game is set to start at 20:15 ET.