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Home / MLB / Cleveland Guardians at Boston Red Sox Predictions & Picks – Red Sox To Avenge Last Night's MLB Loss

Cleveland Guardians at Boston Red Sox Predictions & Picks – Red Sox To Avenge Last Night's MLB Loss

Quick Read

  • Cleveland on a 6-game win streak but Boston has pitching advantage
  • Red Sox's Sonny Gray leads AL with 17 wins, 2.82 ERA
  • Experts pick Boston to win & total runs under 7.5
Leigh Copson
Written by Leigh Copson
Sports Editor25+ Years Experience, US & Combat Sports Specialist
Updated: Sep 23, 2026
mlb guardians red sox
Our TipStrong confidence
Stake.us

Moneyline

Boston Win

Odds

-138.89

Place Bet
Stake.us

Total Runs

Under 7.5

Odds

100.00

Place Bet

Cleveland Guardians at Boston Red Sox Predictions & Picks

Boston are tipped to bounce back from last night’s defeat to Cleveland.

The Guardians are on a roll, but tonight they come up against a Red Sox starter that has been stacking up wins all season and leads the AL in victories.

  • Boston starter Sonny Gray has an American League-leading 17 wins
  • Sonny Gray is 17-5 with a 2.82 ERA a 1.16 WHIP this season
  • The Under has cashed in 9 of Boston’s previous 10 games
  • The two starting pitchers have a combined ERA of 6.49

Head To Head

  • Cleveland Guardians lead the all-time series 1076-1015-8
  • Cleveland Guardians won 3-2 when the two teams last met on September 22

Cleveland Guardians Form

Cleveland enter the second game of this series in great form, having won eight of their previous 10 games and each of the last six.

DateOppositionW/LScore
Sep-11 at Minnesota Twins W 5-2
Sep-12 at Minnesota Twins L 3-4
Sep-13 at Minnesota Twins W 9-2
Sep-14 vs Chicago White Sox L 3-7
Sep-15 vs Chicago White Sox W 7-6 W/O
Sep-16 vs Chicago White Sox W 6-3
Sep-18 vs The Athletics W 5-3
Sep-19 vs The Athletics W 12-6
Sep-20 vs The Athletics W 1-0
Sep-22 at Boston Red Sox W 3-2

Boston Red Sox Form

Boston go into this matchup on the back of their third straight loss, and having now been beaten in six of their last 10 games.

DateOppositionW/LScore
Sep-11 vs Kansas City Royals L 2-3
Sep-12 vs Kansas City Royals W 5-1
Sep-13 vs Kansas City Royals W 4-1
Sep-15 at Texas Rangers L 2-4
Sep-16 at Texas Rangers L 3-7
Sep-17 at Texas Rangers W 4-3
Sep-18 at Tampa Bay Rays W 4-2
Sep-19 at Tampa Bay Rays L 1-2 W/O
Sep-20 at Tampa Bay Rays L 1-5
Sep-22 vs Cleveland Guardians L 2-3

Starting Pitchers

PlayerTeamRecordERAStrikeoutsInnings
Foster Griffin Cleveland Guardians 15-5 3.67 151 166.2
Sonny Gray Boston Red Sox 17-5 2.82 146 163.0

Verdict

Cleveland are in good form and need this win in the race to win the division, but Boston have the pitching advantage here.

Sonny Gray has repeatedly delivered for the Red Sox this season, and can do so again on Wednesday night.

Stake.us
Top Pick

Boston Win

at Stake.us

-138.89Visit Site
Stake.us

Under 7.5

at Stake.us

Leigh Copson
Leigh Copson

Sports Editor25+ Years Experience, US & Combat Sports Specialist

Leigh Copson is the editor of expert picks and provides daily picks for the NFL, NBA, NHL, MLB boxing and MMA. He provides analysis of the big events across major American leagues every day.


He started out with the Press Association before moving online and working for ExpertPicks.com, FreeTips.com and other sports news and betting sites. 

He has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final and has covered almost every major boxing match and UFC fight card during this time.

Follow more of Leigh's work on Muckrack and connect with him on LinkedIn.


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