Arizona Cardinals at San Francisco 49ers Predictions & Picks
San Francisco are tipped to cover as they knock off their NFC West rivals.
The 49ers have won their first two games in blowout fashion, and they can run riot against a Cardinals defense that was gashed by the Seahawks a week ago.
- San Francisco 49ers are 2-0 this season
- San Francisco 49ers are 2-0-0 ATS through 2 weeks
- Arizona Cardinals lost by 24 points last weekend
- The Under has cashed in 3 of the 4 previous games involving either team
Head To Head
- San Francisco 49ers lead the all-time series 38-31
- San Francisco 49ers won 41-22 when the two teams last met in November 2025
Arizona Cardinals Form
Arizona head out on the road for the second time this season looking to rebound from a first loss that dropped them to 1-1.
The Cardinals enjoyed a winning start to the season as they downed the Los Angeles Chargers on the road, 26-14, but they were brought back down to Earth last weekend.
They managed just one touchdown all game as they were beaten 31-7 at NFC West rivals Seattle – who had a backup quarterback running the offense.
Arizona quarterback Jacoby Brissett went 17/28 for just 95 yards, one touchdown and one interception.
On a bad day for the offense, Tre McBride led the receivers with 41 yards and a score, while Jeremiyah Love was the lead rusher with only 29 yards.
San Francisco 49ers Form
San Francisco go into Sunday’s matchup having followed up the victory in Australia with success in their home opener.
The 49ers travelled to Melbourne as underdogs for a meeting with the Los Angeles Rams, but they made the long trip worthwhile with a 27-7 rout of their NFC West rivals.
They then followed up that victory last weekend, as they downed Miami 35-13 to improve to 2-0.
Quarterback Brock Purdy was a very impressive 20/22 for 287 yards and two touchdowns, while also rushing for 30 yards and a score.
Christian McCaffrey contributed 66 total yards, while George Kittle put up 80 yards and a touchdown.