Los Angeles Chargers at Buffalo Bills Predictions & Picks
Buffalo are tipped to cover as they make straightforward work of the Chargers.
Josh Allen and the Bills offense are off to a red-hot start, and they can set a scoring pace that the visitors simply cannot match.
- Buffalo Bills are 2-0-0 ATS this season
- Buffalo Bills have scored 77 points across the first 2 weeks
- Winless Los Angeles Chargers are 0-2-0 ATS so far
- The Over has cashed in each of Buffalo’s first two games
Head To Head
- Los Angeles Chargers lead the all-time series 25-14-2
- Buffalo Bills won 24-22 when the two teams last met in December 23
Los Angeles Chargers Form
Los Angeles head out on the road for the first time this season still seeking a first victory of 2026.
The Chargers opened the campaign with back-to-back home games, but failed to make the most of that as they lost both of them.
They kicked off the campaign with a 26-14 loss to Arizona, and then lost by the exact same score when they hosted division rivals Las Vegas last weekend.
Quarterback Justin Herbert was just 15/27 for 192 yards, one touchdown and two interceptions.
Running back Omarion Hampton did offer one bright spot on offense as he put up 115 total yards and a touchdown in the loss.
Buffalo Bills Form
Buffalo go into their second consecutive home game boasting a perfect record thanks to back-to-back victories.
The Bills opened the season with a trip to face a tough Houston defense, but Josh Allen & Co. was able to light up the Texans to secure a 36-31 victory.
They topped that performance in their home opener last weekend, as they hung 41 points on Detroit in a 41-31 success.
Quarterback Allen went 20/31 for 248 yards and three touchdowns, while also rushing for 69 yards and two touchdowns.
Running back James Cook racked up 135 yards and a touchdown off 21 carries, while Dalton Kincaid caught the ball seven times for 95 yards and a score.