Los Angeles come into this game in need of a victory, having lost their last two games to fall to 2-4.
The Chargers opened up with a 36-34 home defeat to Miami, and then lost 27-24 in overtime in Tennessee.
They finally got off the mark in Week 3 with a 28-24 victory in Minnesota, and they followed that up with a 24-17 success against Las Vegas.
Los Angeles have stalled since then though, heaping pressure on under-fire head coach Brandon Staley.
The Chargers were beaten 20-17 at home by Dallas, and then travelled to Kansas City for a 31-17 defeat to the Chiefs.