Jacksonville come into this on the back of a big win that improved them to 8-3 and strengthened their grip on top spot in the AFC South.
The Jaguars made a slow start to the regular season as they lost two of their first three games, but a London double-header sparked a transformation in fortunes.
They beat Atlanta 23-7 and Buffalo 25-20 in back-to-back weeks in England, before returning home for a 37-20 victory over Indianapolis.
Jacksonville then beat New Orleans 31-24 and Pittsburgh 20-10 on the road, only to see their win streak finally ended with a 34-3 blowout loss to San Francisco.
The Jaguars bounced back quickly though, winning a couple of big division games as they beat Tennessee 34-14 and Houston 24-21.