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Home / College Football / Michigan State at Notre Dame Predictions & Picks – Fighting Irish To Stay Perfect In College Football

Michigan State at Notre Dame Predictions & Picks – Fighting Irish To Stay Perfect In College Football

Quick Read

  • Notre Dame favored to cover big spread after two dominant wins
  • Irish are 2-0 ATS and 5-2 ATS in last 7 as double-digit home favorites
  • Recommended bets: Notre Dame -29.5; Under 52.5 points
Leigh Copson
Written by Leigh Copson
Sports Editor25+ Years Experience, US & Combat Sports Specialist
Updated: Sep 16, 2026
ncaaf michigan state notre dame
Our TipStrong confidence
Stake.us

Spread

Notre Dame -29.5

Odds

-111.11

Place Bet
Stake.us

Total Points

Under 52.5

Odds

-111.11

Place Bet

Michigan State at Notre Dame Predictions & Picks

Notre Dame are tipped to cover a big spread as they improve to 3-0.

The Fighting Irish are firing offensively with CJ Carr at the controls, and this defense has already put the clamps on two opponents this season and can do the same to the Spartans.

  • Notre Dame are 2-0-0 ATS this season
  • Notre Dame have won their first two games by an average of 40 points per game
  • Notre Dame are 5-2-0 ATS in their last 7 home games as a double digit favorite
  • The Under cashed in both teams’ Week 2 matchups

Head To Head

  • Notre Dame lead the all-time series 49-29-1
  • Notre Dame won 38-18 when the two teams last met in September 2017

Michigan State Form

Michigan State head out on the road for the first time this season having opened with back-to-back wins.

The Spartans have faced a couple of opponents from the Mid-American conference, winning both games by double digits.

They opened up with a 30-20 victory over Toledo, and backed that up with a 35-7 blowout of Eastern Michigan last weekend.

Quarterback Alessio Milivojevic went 12/20 for 170 yards and two touchdowns, with Charles Taplin accounting for 65 receiving yards and a score.

Camryn Edwards was the star performer on the day for Michigan State, as he racked up 152 rushing yards and a couple of touchdowns.

Notre Dame Form

Notre Dame enter this matchup boasting a perfect record thanks to a couple of blowout victories.

The Fighting Irish opened up the campaign by facing Wisconsin at Lambeau Field, and ran out 41-13 winners.

They followed that up with another one-sided win in their home opener, as they shut out Rice in a 52-0 victory.

CJ Carr went 16/20 for 253 yards and four touchdowns before exiting the game, and by the end of the game 12 different players had caught a pass.

Jonaz Walton led the team in rushing with 48 yards off eight carries, while Nolan James Jr turned two of his seven touches into touchdowns.

Verdict

Our Verdict
Notre Dame have blown out their first two opponents, and more of the same is expected here.

Another efficient offensive performance and dominant defensive display can ensure a win and cover for the Fighting Irish.

Stake.us
Top Pick

Notre Dame -29.5

at Stake.us

-111.11Visit Site
Stake.us

Under 52.5

at Stake.us

-111.11Visit Site
Leigh Copson
Leigh Copson

Sports Editor25+ Years Experience, US & Combat Sports Specialist

During his career he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final. He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.


Follow more of Leigh's work on Muckrack.

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