SMU at Louisville Predictions & Picks
Louisville are tipped to cover the spread as they make it back-to-back wins.
The Cardinals will be motivated by last season’s blowout loss, and in Lincoln Kienholz they have a quarterback that can lead them to victory in a shootout.
- Louisville are 2-0-0 ATS this season
- Louisville have scored 97 points across their first two games
- The Over has hit in both of Louisville’s games so far
Head To Head
- SMU lead the all-time series 4-0
- SMY won 38-6 when the two teams last met in November 2025
SMU Form
SMU head to Louisville looking to make it three straight wins and improve their conference record to 2-0.
The Mustangs opened up with an ACC matchup against Florida State on the road, and returned home with a 27-24 victory.
They followed that up last weekend with a 56-10 blowout of UC-Davis in their home opener.
Kevin Jennings went 14/16 for 337 yards and five touchdowns before exiting the game, and by the end of the game no less than 16 players had caught a pass.
Theo Melln Ohrstrom had two touchdowns off his three grabs, while Derrick McFall showcased his dual threat with 103 total yards and a touchdown.
Louisville Form
Louisville go into their home opener on the back of their first win of the season, which improved them to 1-1.
The Cardinals were handed a tough opener in the form of a showdown with top-10 Ole Miss, and although they lost they were far from disgraced.
They pushed the Rebels to the limit in the second half, before finally falling to a 41-38 defeat.
Louisville faced less of a challenge last week as they opened up at home to Villanova, and it was no surprise to see them win by a large margin, 59-13.
Lincoln Kienholz went 16/21 for 332 yards and two touchdowns, while also playing his part on the ground as he rushed for 42 yards and two more scores.