Notre Dame at Purdue Predictions & Picks
Notre Dame are tipped to cover a big spread as they down Purdue on the road.
The Fighting Irish can run all over this bad Boilermarker rush defense, while the visitors’ own defense puts the clamps on the home offense and forces key turnovers.
- Notre Dame are 2-1-0 ATS in their first 3 games
- Notre Dame have won each of the previous 10 meetings
- Notre Dame are 2-0-0 ATS against Purdue in each of the last 2 seasons
- The Over has cashed in each of the last 2 meetings
Head To Head
- Notre Dame lead the all-time series 61-26-2
- Notre Dame won 56-30 when the two teams last met in September 2025
Notre Dame Form
Notre Dame face Big Ten opposition for the second weekend in a row, looking to improve their record to 4-0.
The Fighting Irish kicked off the season by visiting Lambeau Field for a showdown with Wisconsin, which they won 41-13.
They followed that up with a shutout victory in their home opener a week later, beating Rice 52-0.
Notre Dame than made it three-in-a-row last weekend, as they downed Michigan State, 27-10, in South Bend.
Running back Nolan James Jr did the damage on the ground as he rushed for 121 yards and a touchdown.
Purdue Form
Purdue go into Saturday’s game having failed to build on a season-opening win, losing back-to-back games.
The Boilermakers opened the campaign at home and enjoyed a successful start as they downed Indiana State 44-19.
They failed to follow that up a week later though, as they suffered a narrow 38-36 defeat at the hands of Wake Forest.
It then became consecutive losses for Purdue last weekend, as they were beaten 52-38 by UCLA in their road opener.
Quarterback Ryan Browne went 19/30 for 378 yards, three touchdowns and an interception, with Xavier Townsend hauling in six catches for 162 yards and two scores.