Detroit head to Los Angeles on the back of a victory that improved their record to 6-2.
The Lions sent a message to the rest of the NFL on opening night as they upset defending champions Kansas City, 21-20, on the road.
They were quickly brought back down to Earth by a 37-31 overtime loss to Seattle in their home opener, but they responded well, sparking a four-game streak with a 20-6 win over Atlanta.
Detroit then won 34-20 in Green Bay, 42-24 at home to Carolina and 20-6 at Tampa Bay, before suffering a miserable 38-6 blowout defeat in Baltimore.
The Lions rebounded swiftly from that embarrassing loss though, downing Las Vegas 26-14 for their sixth win of the season.