San Francisco 49ers at Seattle Seahawks Predictions & Picks
San Francisco are tipped to cover as a betting underdog in Seattle.
The Seahawks have the “12th Man” advantage, and they have largely looked good on both sides of the football through the first four weeks of the season.
But so have the 49ers, and they have all of the key pieces in place on the offense at this time.
- San Francisco 49ers are 4-0 this season
- San Francisco 49ers are 3-1-0 ATS through 4 games
- San Francisco 49ers are 4-1 in the last 5 meetings in Seattle
- The Under has cashed in 3 of the previous 4 meetings
Head To Head
- Seattle Seahawks lead the all-time series 33-24
- Seattle Seahawks won 13-3 when the two teams last met in January 2026
San Francisco 49ers Form
San Francisco head to the Pacific Northwest boasting a 100% record thanks to four consecutive victories.
The 49ers made the long trip to Australia for opening day, but they made it a worthwhile visit as they downed the Los Angeles Rams in Melbourne, 27-7.
They backed that up a week later in their home opener, as they made light work of Miami in a 35-13 victory.
That was the start of a run of three consecutive home games for San Francisco, and they have taken full advantage.
The 49ers knocked off another division rival as they beat Arizona 36-30, and that was followed by a 24-14 success when they hosted Denver last weekend.
Seattle Seahawks Form
Seattle go into this big NFC West clash having rebounded from their first defeat of the season to improve to 3-1.
The Seahawks – who won the Super Bowl last season – began their defence of the crown with a 13-10 win over New England.
They then backed that up in their road opener a week later, as they visited Arizona and blew out the Cardinals, 31-7.
Seattle failed to make it three-in-a-row as they were beaten 33-31 at Washington in Week 3, but they issued an immediate response to that.
The Seahawks got back to winning ways last Sunday as they beat the Los Angeles Chargers 30-23 at home.