Seattle Seahawks at Arizona Cardinals Predictions & Picks
Arizona are tipped to cover as a home betting underdog.
The Cardinals played some good football on both sides of the ball in their surprise Week 1 win, and now they get to face a Seahawks team with error-prone Drew Lock under center.
- Arizona Cardinals are 1-0-0 ATS as a betting underdog
- Seattle Seahawks are 0-1-0 ATS so far this season
- The Under cashed in Arizona’s opening game
- The Under hit in Seattle’s first game of the season
Head To Head
- Seattle Seahawks lead the all-time series 31-22-1
- Seattle Seahawks won 44-22 when the two teams last met in November 2025
Seattle Seahawks Form
Seattle head out on the road for the first time this season, looking to build on their Week 1 win over New England.
The Seahawks and Patriots went head-to-head in rematch of last season’s Super Bowl, and the hosts again came out on top as they won 13-10.
They trailed by 10 points late in the third quarter, but turned things around as two Jason Myers field goals sandwiched a Jaxon Smith-Njigba touchdown catch.
Sam Darnold left the game with injury, and in his place Drew Lock went 16/22 for 187 yards and a touchdown.
Smith-Njigba led the team in receiving with 122 yards and a score, while Jadrian Price put up 52 yards off 10 carries.
Arizona Cardinals Form
Arizona go into their home opener on the back of an impressive season-opening win at the Los Angeles Chargers.
The Cardinals went into that match as 9.5-point underdogs, but produced a well-rounded display to run out 26-14 winners at SoFi Stadium.
Jacoby Brissett – named the starter in the offseason – went 27/37 for 277 yards and a touchdown.
Trey McBride was his favourite target, turning 13 targets into nine catches, 95 yards and a touchdown, while Omarion Hampton rushed for 43 yards and a score on 12 carries.
Over on defense, Jordan Burch and Dante Stills had a sack each, while Andrew Wingard registered an interception and forced a fumble that Will Johnson recovered.