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Home / College Football / Iowa State at Iowa Predictions & Picks – Back Hawkeyes For Cy-Hawk Cover In College Football

Iowa State at Iowa Predictions & Picks – Back Hawkeyes For Cy-Hawk Cover In College Football

Quick Read

  • Iowa State at Iowa picks for Saturday, September 12
  • Game is taking place at Kinnick Stadium
  • Preview, predictions, stats & form
Leigh Copson
Written by Leigh Copson
Sports Editor25+ Years Experience, US & Combat Sports Specialist
Updated: Sep 10, 2026
Iowa State at Iowa Predictions & Picks – Back Hawkeyes For Cy-Hawk Cover In College Football

(Getty Images)

Our TipStrong confidence
Stake.us

Spread

Iowa -13.5

Odds

-120.48

Place Bet
Stake.us

Total Points

Under 55.5

Odds

-111.11

Place Bet

Iowa State at Iowa Predictions & Picks

Iowa are tipped to win by at least two touchdowns in the latest Cy-Hawk showdown.

The Cyclones were raided by Penn State in the offseason, losing their coach and over 20 players, and this new-look group lacks experience and quality heading into this matchup.

  • Iowa are 10-30 ATS in their last 13 games
  • Iowa State failed to cover in their season opener
  • The Under has cashed in 6 of the previous 7 meetings
  • The Under hit in both teams’ season opener

Head To Head

  • Iowa lead the all-time series 47-25
  • Iowa State won 16-13 when the two teams last met in September 2025

Iowa State Form

Iowa State kicked off a new era for the programme with a 38-10 victory over Southeast Missouri last weekend.

The Cyclones underwent significant changes in the offseason as they lost head coach Matt Campbell and over 20 players to Penn State.

Jimmy Rogers was named Campbell’s successor and was immediately tasked with replacing all of the talent that was lost to the Nittany Lions.

This new-look Iowa State roster got off to a winning start a week ago, but they toiled offensively on their way to a 38-10 victory over SEMO.

New starting quarterback Jaylen Raynor completed just eight passes for 184 yards and two touchdowns, while contributing 32 rushing yards and a couple of scores.

Iowa Form

Iowa enter the Cy-Hawk matchup having opened their 2026 campaign with a shutout victory.

The Hawkeyes played host to Northern Illinois last Saturday, and a victory was never in any doubt following a dominant first quarter.

They put up 20 unanswered points in the opening period, and added 13 more in the second to take a commanding 33-0 lead into the break.

Iowa then took their foot off the gas following the restart, adding just one more touchdown to wrap up a 40-0 victory.

Running back Kamari Moulton was the start of the show for the Hawkeyes, as he ran for 183 yards and two touchdowns off just 11 carries.

Verdict

Our Verdict
Iowa State are expected to put up more resistance than Northern Illinois, but Iowa are still backed to win this comfortably.

This is the weakest Cyclones team that the Hawkeyes have faced in a while, and they can take full advantage of that.

Stake.us
Top Pick

Iowa -13.5

at Stake.us

-120.48Visit Site
Stake.us

Under 55.5

at Stake.us

-111.11Visit Site
Leigh Copson
Leigh Copson

Sports Editor25+ Years Experience, US & Combat Sports Specialist

During his career he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final. He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.


Follow more of Leigh's work on Muckrack.

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