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Home / College Football / Oregon at Oklahoma State Predictions & Picks – Ducks To Repeat 2025 Blowout Of Cowboys In College Football

Oregon at Oklahoma State Predictions & Picks – Ducks To Repeat 2025 Blowout Of Cowboys In College Football

Quick Read

  • Oregon at Oklahoma State picks for Saturday, September 12
  • Game is taking place at Boone Pickens Stadium
  • Preview, predictions, stats & form
Leigh Copson
Written by Leigh Copson
Sports Editor25+ Years Experience, US & Combat Sports Specialist
Updated: Sep 10, 2026
Oregon at Oklahoma State Predictions & Picks – Ducks To Repeat 2025 Blowout Of Cowboys In College Football

(Getty Images)

Our TipStrong confidence
Stake.us

Spread

Oregon -23.5

Odds

-111.11

Place Bet
Stake.us

Total Points

Over 57.5

Odds

-111.11

Place Bet

Oregon at Oklahoma State Predictions & Picks

Oregon are tipped to cover as they crush Oklahoma State for the second season in a row.

The Ducks underwhelmed on opening weekend, but they are better than that performance suggests, while another season of struggle appears to be on the cards for the Cowboys.

  • Oregon beat Oklahoma by 66 points last season
  • Oklahoma State are on a 12-game losing skid
  • Oklahoma State lost as a 13.5 favorite last week
  • The Over cashed in last season’s meeting

Head To Head

  • Oregon lead the all-time series 2-0
  • Oregon won 69-3 when the two teams last met in September 2025

Oregon Form

Oregon kicked off their campaign with a victory last weekend, but they made hard work of it.

The Ducks went into the meeting with Boise State as a 25.5 point favourite, but trailed by as many as 10 points during the first half, before going into the break 17-14 down.

They rallied after the restart, but the Broncos stuck around and it took a 62-yard touchdown pass in the fourth quarter to finally break their resistence.

Oregon won it 34-27, with quarterback Dante Moore going 28/37 for 378 yards and three touchdowns.

Jeremiah McClellan led the team in receiving with 150 yards and a touchdown off six grabs, while Jordan Davison contributed 90 yards and a TD on the ground.

Oklahoma State Form

Oklahoma State go into their home opener having seen their losing skid resume with a surprise defeat last weekend.

The Cowboys suffered a heavy loss when they hosted Oregon in Week 2 of last season, and that proved to be the start of an 11-game losing run to close out the campaign.

They went into their 2026 opener as a double digit favorite despite that miserable record, but they picked up from where they left off with another defeat, losing 24-10 to Tulsa.

Starting quarterback Drew Mestemaker went 29/49 for 241 yards, one touchdown and two interceptions in the loss.

Caleb Hawkins rushed for 79 yards off 18 carries, while Wyatt Young led the team in receiving with 84 yards off eight grabs.

Verdict

Our Verdict
Oregon crushed Oklahoma State when these two teams met last season, and we expect more of the same here.

The Ducks are expected to show significant improvement following that struggle with Boise State, and that is likely to result in a one-sided win for the visitors.

Stake.us
Top Pick

Oregon -23.5

at Stake.us

-111.11Visit Site
Stake.us

Over 57.5

at Stake.us

-111.11Visit Site
Leigh Copson
Leigh Copson

Sports Editor25+ Years Experience, US & Combat Sports Specialist

During his career he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final. He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.


Follow more of Leigh's work on Muckrack.

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