Iowa State vs Kentucky Predictions & Picks - Cyclones To See Of Wildcats In March Madness

leigh-copson
21 Mar 2026
Leigh Copson 21 Mar 2026
Share this article
Or copy link
  • Iowa State vs Kentucky picks for Sunday, March 22
  • Game is taking place at Enterprise Center in St Louis, Missouri
  • Preview, predictions, stats & form
(Getty Images)

Iowa State vs Kentucky Predictions & Picks

Iowa State are tipped to cover as they win this second-round clash.

The Cyclones are sweating over the health of Joshua Jefferson, but in what could be a clash that goes right down to the wire, we are taking the team that did not need an emotional overtime winner to stay alive in round one.

  • Iowa State have covered in 5 straight games
  • Kentucky are 2-6-0 ATS in their 8 games as a betting underdog
  • The Over has hit in 3 of Iowa State's last 5 games
  • The Over has cashed in each of Kentucky's last 3 games

Head To Head

  • Kentucky lead the all-time series 3-0
  • Kentucky won 87-71 when the two teams last met in March 2012

Iowa State Form

DateOppositionW/LScoreCompetition
Feb-16HoustonW70-67Regular Season
Feb-21BYUL69-79Regular Season
Feb-24UtahW75-59Regular Season
Feb-28Texas TechL73-82Regular Season
Mar-02ArizonaL57-73Regular Season
Mar-07Arizona StateW86-65Regular Season
Mar-11Arizona StateW91-42Conference Tournament
Mar-12Texas TechW75-53Conference Tournament
Mar-13ArizonaL80-82Conference Tournament
Mar-20Tennessee StateW108-74
NCAA Tournament

Kentucky Form

DateOppositionW/LScoreCompetition
Feb-17GeorgiaL78-86
Regular Season
Feb-21AuburnL74-75
Regular Season
Feb-24South CarolinaW72-63
Regular Season
Feb-28VanderbiltW91-77
Regular Season
Mar-03Texas A&ML85-96
Regular Season
Mar-07FloridaL77-84
Regular Season
Mar-11LSUW87-82
Conference Tournament
Mar-12MissouriW78-72
Conference Tournament
Mar-13FloridaL63-71
Conference Tournament
Mar-20Santa ClaraW89-84
NCAA Tournament

Verdict

Joshua Jefferson's health is a big question mark for the Cyclones after round one.

They got the job done though, and we are backing them to battle past a Kentucky team that could be a little weary after their dramatic overtime win in the first round.

Best Bet1: Iowa State -5.0 Spread @-111.11 at Stake.us - 4 Units
Best Bet2: Over 146.0 Total Points @-111.11 at Stake.us - 2 Units
Iowa State -5.0
Spread
@-111.11 - 4 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us
Over 146.0
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us

Upcoming Events

20 September 2026