Michigan State vs Louisville Predictions & Picks – Spartans To Clip Cardinals’ Wings In March Madness

leigh-copson
1 hour ago
Leigh Copson 1 hour ago
Share this article
Or copy link
  • Michigan State vs Louisville picks for Saturday, March 21
  • Game is taking place at KeyBank Center in Buffalo, New York
  • Preview, predictions, stats & form
(Getty Images)

Michigan State vs Louisville Predictions & Picks

Michigan State are tipped to cover as they march on to the Sweet 16.

The Spartans can dominate in the paint at both ends of the court, and they also defend the three-ball well, which is crucial against this banged-up Louisville group.

  • Michigan State are 6-2 in their last 8 games
  • Michigan State are 4-2-0 ATS in their last 6 games
  • Louisville are 1-3-0 ATS as a betting underdog
  • The Over has cashed in each of Michigan State’s last 4 games

Head To Head

  • The all-time series is tied at 6-6
  • Michigan State won 73-64 when the two teams last met in December 2021

Michigan State Form

DateOppositionW/LScoreCompetition
Feb-07 Illinois W 85-82 OT Regular Season
Feb-13 Wisconsin L 71-92 Regular Season
Feb-17 UCLA W 82-59 Regular Season
Feb-22 Ohio State W 66-60 Regular Season
Feb-26 Purdue W 76-74 Regular Season
Mar-01 Indiana W 77-64 Regular Season
Mar-05 Rutgers W 91-87 Regular Season
Mar-08 Michigan L 80-90 Regular Season
Mar-13 UCLA L 84-88 Conference Tournament
Mar-19 North Dakota State W 92-67 NCAA Tournament

Louisville Form

DateOppositionW/LScoreCompetition
Feb-14 Baylor W 82-71 Regular Season
Feb-17 Southern Methodist L 85-95 Regular Season
Feb-21 Georgia Tech W 87-70 Regular Season
Feb-23 North Carolina L 74-77 Regular Season
Feb-28 Clemson L 75-80 Regular Season
Mar-03 Syracuse W 77-62 Regular Season
Mar-07 Miami FL W 92-89 Regular Season
Mar-11 Southern Methodist W 62-58 Conference Tournament
Mar-12 Miami FL L 73-78 Conference Tournament
Mar-19 South Florida W 83-79 NCAA Tournament

Verdict

Louisville produced an upset in the opening round, but we are not expecting a repeat in round two.

Michigan State are adept at taking away perimeter shooting – which the Cardinals rely on – and they can also control the contest under the glass, turning missed shots into transition points.

Best Bet1: Michigan State -4.0 Spread @-111.11 at Stake.us - 4 Units
Best Bet2: Over 150.5 Total Points @-111.11 at Stake.us - 2 Units
Michigan State -4.0
Spread
@-111.11 - 4 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us
Over 150.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us

Upcoming Events

20 March 2026

21 March 2026

27 March 2026

2026 MLB World Series Betting Preview Baseball 2026 MLB World Series Odds – LA Dodgers Favourites For 3-Peat

20 September 2026