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LSU at Ole Miss Preview & Picks – Tigers To Take Down Rebels In College Football

leigh-copson
2 hours ago
leigh-copson
Leigh Copson 2 hours ago
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  • LSU at Ole Miss picks for Saturday, September 27
  • Game is taking place at Vaught–Hemingway Stadium
  • Preview, predictions, stats & form
(Getty Images)
    LSU at Ole Miss Preview & Picks
  • LSU at Ole Miss Preview & Picks
  • Head To Head
  • LSU Form
  • Ole Miss Form

LSU at Ole Miss Preview & Picks

LSU are tipped to win as a slight underdog in Mississippi.

Tigers quarterback Garrett Nussmeier is getting back to full fitness, and this defense has been dominant through the first few weeks of the season.

  • LSU are 4-0 so far this season
  • LSU are 7-2 in the last 9 meetings with Ole Miss
  • The Under has hit in 3 of LSU’s previous 4 games
  • The Under has cashed in 3 of the last 4 meetings

Head To Head

  • LSU lead the all-time series 64-42-4
  • LSU won 29-26 in overtime when the two teams last met in October 2024

LSU Form

LSU make the trip to Mississippi having reeled off four consecutive wins to start the 2025 season.

The Tigers missed out on the playoffs in the previous two seasons, but with pressure mounting on Brian Kelly they have got off to a flying start this time around.

They made an immediate statement as they kicked off the season with a 17-10 victory in Clemson.

LSU backed that up a week later as they downed Louisiana Tech 23-7, and then followed that up with a 20-10 victory when they played host to Florida.

The Tigers improved to 4-0 last weekend as they made straightforward work of Southeastern Louisiana, winning 56-10.

Ole Miss Form

Ole Miss go into this matchup having already won a couple of conference games during a perfect start to the season.

Like LSU, the Rebels are also looking to end their postseason exile this season, and they have kicked things off with four consecutive victories.

They made straightforward work of Georgia State on opening weekend as they ran out 63-7 winners.

Ole Miss then backed that up with back-to-back victories to start their SEC campaign, winning 30-23 in Kentucky and 41-35 at home to Arkansas.

The Rebels then made it to four-in-a-row last weekend as they blew out Tulane at home, winning 45-10.

Verdict

Ole Miss are off to a solid start, but the Tigers have shown they are serious contenders for the national crown.

A big reason is a defense that continues to put the clamps on the opposition, and it is a big reason why we are confident about their chances as an underdog.

Best Bet1: LSU Win Moneyline @110.00 at Stake.us - 4 Units
Best Bet2: Under 55.5 Total Points @-111.11 at Stake.us - 2 Units
LSU Win
Moneyline
@110.00 - 4 Units
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Bet at Stake.us
Under 55.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us