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12 Dec 2025
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Notre Dame at Clemson Preview & Picks – Fighting Irish To Tame Tigers In College Football
- Notre Dame at Clemson picks for Saturday, November 4
- Matchup gets underway at 12:00 ET at Memorial Stadium
- Preview, predictions, stats & form
- Notre Dame at Clemson Preview & Picks
- Head To Head
- Notre Dame Form
- Clemson Form
Notre Dame at Clemson Preview & Picks
Notre Dame at Clemson Preview & Picks
Notre Dame are tipped to cover as they win in ‘Death Valley’.
The Fighting Irish can ride their dominant run game and tough defense to victory over a Clemson team who have taken another step backwards in 2023.
- Notre Dame are 6-2-0 ATS as a betting favorite
- Clemson are 2-3 in their last 5 games
- Clemson 1-4-0 ATS in their last 5 games
- The Under has hit in 3 of Notre Dame’s 4 games away from South Bend
Head To Head
- Clemson lead the all-time series 4-3
- Notre Dame won 35-14 when the two teams last met in November 2022
Notre Dame Form
Notre Dame head back out on the road looking to follow up consecutive wins that have improved them to 7-2.
The Fighting Irish opened the season with a 42-3 blowout of Navy in Ireland, and that was followed up by a 56-3 demolition of Tennessee State.
They then won 45-24 at NC State and beat Central Michigan 41-17 at home, only to blow a late lead to lose 17-14 at home to #6 Ohio State a week later.
Notre Dame bounced back with a 21-14 success at #17 Duke, but they were unable to back at that up as they then lost 33-20 at #25 Louisville.
The Fighting Irish have got back on track though, following up a 48-20 rout of #10 USC with a 58-7 beat down of Pittsburgh.
Clemson Form
Clemson return home on the back of a couple of road defeats that have left them with a 4-4 record.
The Tigers kicked off the season with a surprise 28-7 defeat at Duke, only to bounce back with a 66-17 win against Charleston Southern in their home opener.
They then made it back-to-back wins by beating Florida Atlantic 48-14, but came up short when they hosted #Florida State a week later, 31-24.
Clemson hit back with a 31-14 success at Syracuse, and then followed that up with a 17-12 victory at home to Wake Forest.
The Tigers have not won since though, losing 28-20 at Miami (FL), before heading to NC State for a 24-17 defeat.
Verdict
Betting against Clemson at home has been a risky move in recent years, but they are a shadow of their former selves.
Notre Dame are rolling behind their run game and the defense, so we are backing the Fighting Irish with confidence.
Notre Dame are rolling behind their run game and the defense, so we are backing the Fighting Irish with confidence.
Notre Dame -3.0
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@-111.11 - 4 Units
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@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
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Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.
See also
- Missouri at Georgia Preview & Picks – Georgia To Miss Out College Football Cover Again
- Washington at USC Preview & Picks – Washington To Boost College Football Playoffs Bid
- Purdue at Michigan Preview & Picks – Michigan To Extend College Football Cover Streak
- Florida State at Pittsburgh Preview & Picks – Seminoles To Smash Pitt In College Football
- Ohio State at Rutgers Preview & Picks – Buckeyes To Record College Football Cover
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