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22 Sep 2025
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Oregon at Penn State Preview & Picks – Nittany Lions To Take Big College Football Clash
- Oregon at Penn State picks for Saturday, September 27
- Game is taking place at Beaver Stadium
- Preview, predictions, stats & form
(Getty Images)
- Oregon at Penn State Preview & Picks
- Head To Head
- Oregon Form
- Penn State Form
Oregon at Penn State Preview & Picks
Oregon at Penn State Preview & Picks
Penn State are tipped to cover as they win this massive college football matchup.
James Franklin has all of the pieces in place for a run at a national championship, and they can make an early statement by taking down Oregon at home.
- Penn State are 3-0 so far this season
- Oregon are 0-1-0 ATS on the road this season
- Oregon are 2-3-0 ATS in their 5 conference road games since entering the Big Ten
- The Over cashed in last season’s meeting
Head To Head
- Penn State lead the all-time series 3-2
- Oregon won 45-37 when the two teams last met in December 2024
Oregon Form
Oregon make the trip to Happy Valley boasting a perfect 4-0 record and having already won their Big Ten opener on the road.
The Ducks enjoyed a successful first year in the Big Ten as they beat Penn State 45-37 in the 2024 conference championship, but that failed to translate that into playoff success as they lost in the Rose Bowl.
They came into the new season as a leading contender to go all the way, and after four games they are sitting pretty with a perfect record.
Oregon opened with a 59-13 win over Montana State, before dominating Oklahoma State in a 69-3 blowout.
The Ducks then made it three-in-a-row as they went out on the road to beat Northwestern 34-14 in their Big Ten opener, and it became 4-0 last weekend as they downed Oregon State, 41-7.
Penn State Form
Penn State enter their opening conference game with a flawless record, having won each of their first three games.
The Nittany Lions lost in the Big Ten Championship Game last season, but rallied in the playoffs with back-to-back wins before their run was ended by an Orange Bowl loss.
Despite falling short a year ago they remain one of the top contenders for a national crown in 2025, and they have so far lived up to expectations.
Penn State have kicked off the season with three straight home wins, starting with a 46-11 victory over Nevada.
The Nittany Lions then backed that up with a 34-0 shutout win over Florida International, before blowing out Villanova last weekend, 52-6.
Verdict
Oregon are clearly Penn State’s toughest yet, but the same can be said the other way.
The Nittany Lions have home advantage and they can take down an Oregon team that have struggled for road covers in Big Ten action.
The Nittany Lions have home advantage and they can take down an Oregon team that have struggled for road covers in Big Ten action.
Penn State -3.5
Spread
@-111.11 - 4 Units
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Over 52.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS
Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.
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