Betting

Purdue at Notre Dame Preview & Picks – Irish To Miss Out On College Football Cover

leigh-copson
16 Sep 2025
leigh-copson
Leigh Copson 16 Sep 2025
Share this article
Or copy link
  • Purdue at Notre Dame picks for Saturday, September 20
  • Game is taking place at Notre Dame Stadium
  • Preview, predictions, stats & form
(Getty Images)
    Purdue at Notre Dame Preview & Picks
  • Purdue at Notre Dame Preview & Picks
  • Head To Head
  • Purdue Form
  • Notre Dame Form

Purdue at Notre Dame Preview & Picks

Purdue are backed to cover the spread as a big underdog.

The Boilermakers are improved from the group that got steamrollered by the Irish a year ago, and the home team need to show more before we can back them as huge favourites.

  • Notre Dame are 0-2-0 ATS this season
  • Purdue are 2-1-0 ATS in their first 3 games
  • Purdue are 3-1-0 ATS in their last 4 visits to Notre Dame
  • The Over has cashed in Notre Dame’s first 2 games

Head To Head

  • Notre Dame lead the all-time series 58-26-2
  • Notre Dame won 66-7 when the two teams last met in September 2024

Purdue Form

Purdue head to South Bend on the back of their first defeat of the season, which dropped them to 2-1.

The Boilermakers won their season-opener a year ago, only to then suffer 11 straight defeats to finish the season with a 1-11 record.

They have already improved on that total this time around, having won each of their first two games.

Purdue kicked off the campaign with a 31-0 shutout win over Ball State, and they backed that up a week later by beating Southern Illinois 34-17.

The Boilermakers failed to make it three-in-a-row though, as they lost 33-17 to USC in their Big Ten opener.

Notre Dame Form

Notre Dame enter this matchup in desperate need of a victory, having opened their campaign with consecutive defeats.

The Fighting Irish made it all the way to the National Championship last season, where they ultimately lost to Ohio State, but their hopes of a return to the big game this season have taken some early blows.

Marcus Freeman’s team has opened with back-to-back losses and are now on the brink of crashing out of AP’s top 25.

Notre Dame kicked off the campaign with a trip to face bitter rivals Notre Dame and fell to a 27-24 defeat at the hands of the Hurricanes.

That became back-to-back defeats for the Fighting Irish last weekend, as they lost their home opener to Texas A&M, 41-40.

Verdict

Notre Dame are expected to get off the mark here, but we lack confidence in them covering.

They have dropped back-to-back games, are yet to cover and this Purdue team has shown improvement through the first few weeks of the season.

Best Bet1: Purdue +26.5 Spread @-111.11 at Stake.us - 3 Units
Best Bet2: Over 55.0 Total Points @-111.11 at Stake.us - 3 Units
Purdue +26.5
Spread
@-111.11 - 3 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us
Over 55.0
Total Points
@-111.11 - 3 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us