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Atlanta Falcons at San Francisco 49ers Preview & Picks – NFL Sunday Night Football Success For Niners

leigh-copson
16 Oct 2025
leigh-copson
Leigh Copson 16 Oct 2025
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  • Atlanta Falcons at San Francisco 49ers picks for Sunday, October 19
  • Game is taking place at Levi's Stadium
  • Preview, predictions, stats & form
(Getty Images)
    Atlanta Falcons at San Francisco 49ers Preview & Picks
  • Atlanta Falcons at San Francisco 49ers Preview & Picks
  • Head To Head
  • Atlanta Falcons Form
  • San Francisco 49ers Form

Atlanta Falcons at San Francisco 49ers Preview & Picks

San Francisco are tipped to cover as they rebound from the loss in Tampa.

The 49ers could receive a significant boost with several players in line to return from injury on offense, while Robert Salah’s defense can make life tough for Michael Penix Jr.

  • San Francisco 49ers have a 4-2 record
  • Atlanta Falcons are 1-5-1 ATS in their last 7 road games
  • The Under has cashed in 4 of Atlanta’s 5 games so far

Head To Head

  • San Francisco 49ers lead the all-time series 48-33-1
  • Atlanta Falcons won 28-14 when the two teams last met in October 2022

Atlanta Falcons Form

Atlanta make the trip to California on the back of an impressive victory that improved their record to 3-2.

The Falcons kicked off the season at home, but failed to make the most of it as they were beaten 23-20 by Tampa Bay.

They rebounded on the road a week later, upsetting Minnesota 22-6, only to make an immediate return to losing ways as they were shut out in a 30-0 defeat in Carolina.

Atlanta responded swiftly though, beating Washington 34-27 to enter the bye week at .500.

The Falcons then made it back-to-back wins last weekend, as they returned from the bye with a 24-14 upset of Buffalo on Monday Night Football.

San Francisco 49ers Form

San Francisco return home looking to rebound from a defeat in Tampa that dropped their record to 4-2.

The 49ers opened with back-to-back road games, but made a successful start as they won 17-13 in Seattle and 26-21 in New Orleans.

They then made it three-in-a-row in their home opener, as they downed division rivals Arizona, 16-15.

San Francisco’s perfect start was ended by a 26-21 loss in Jacksonville, but they rallied a week later to beat the Los Angeles Rams in overtime on the road, 26-23.

However, the 49ers were unable to back that up last Sunday, as they fell to a 30-19 defeat at the Buccaneers.

Verdict

Atlanta pulled off a big upset last Monday, but we expect San Francisco to bring them back down to Earth here.

The 49ers welcome back some significant pieces on offense, and that can help cover for a short-handed defense that just lost another key player.

Best Bet1: San Francisco -3.0 Spread @-111.11 at Stake.us - 4 Units
Best Bet2: Under 45.0 Total Points @-111.11 at Stake.us - 2 Units
San Francisco -3.0
Spread
@-111.11 - 4 Units
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Bet at Stake.us
Under 45.0
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us