2026 NFL Draft Odds – Fernando Mendoza Overwhelming Favorite To Be Number 1 Pick After Indiana Success
21 Jan 2026Read More
Buffalo Bills at Detroit Lions Preview & Picks – Buffalo To Cover In NFL Thanksgiving Clash
- Buffalo Bills at Detroit Lions picks for Thursday, November 24
- Thanksgiving Day game gets underway at 12:30 ET at Ford Field
- Preview, stats & head-to-head
- Buffalo Bills at Detroit Lions Preview & Picks
- Head To Head
- Buffalo Bills Form
- Detroit Lions Form
- Buffalo Bills at Detroit Lions FAQs
Buffalo Bills at Detroit Lions Preview & Picks
Buffalo Bills at Detroit Lions Preview & Picks
Buffalo are tipped to cover in a Thanksgiving Day win.
Detroit have found some form recently, but the Bills are the best team they have faced in a while.
The Bills got back on track last weekend, ironically in Detroit, and they are backed to build on that.
- Buffalo are 6-1-1 ATS in their last 8 games vs teams with a losing record
- Detroit are 0-2-0 ATS in non-conference games this season
- The Over has hit in each of Buffalo’s last 2 games
- The Over has cashed in 9 of Detroit’s last 12 games
Head To Head
- Buffalo Bills lead the all-time series 6-4-1
- Buffalo Bills won 14-13 when the teams last met in December 2018
Buffalo Bills Form
Buffalo are looking to build on last weekend’s win as they play in Detroit for the second week running.
The Bills won six of their first seven games of the season, but saw their form cool off after the 27-17 win against Green Bay.
They lost back-to-back games to slip to 6-3 – a sequence that started with a shock 20-17 defeat at the New York Jets.
Buffalo then returned home for a 33-30 overtime loss to Minnesota that saw them press 'self-destruct’.
The Bills were able to get back on track last weekend though, despite bad weather forcing the relocation of their game to Detroit at short notice.
Buffalo’s run game dominated proceedings as they ran out 31-23 winners against Cleveland.
Detroit Lions Form
Detroit have breathed some life into their season recent weeks and have put themselves in the playoff hunt.
The Lions went on a five-game losing skid between late September and late October as they fell to 1-6.
They have rebounded spectacularly in November though, kick-starting their campaign with three consecutive wins.
Detroit picked off Aaron Rodgers three times as they snapped their skid with a 15-9 victory against Green Bay.
They then came back from 14 points down in the fourth quarter in Chicago, scoring three touchdowns in the final period to snatch a 31-30 victory.
The Lions then made it three-in-a-row last weekend as they knocked off the New York Giants, 31-18, on the road.
Buffalo Bills at Detroit Lions FAQs
Where can I watch the Buffalo Bills at Detroit Lions live stream?
You can watch the Buffalo Bills at Detroit Lions live stream at Stake.
What is the Buffalo Bills at Detroit Lions start time?
The Buffalo Bills at Detroit Lions game is set to start at 12:30 ET.
Verdict
Detroit are in good form, but Buffalo are a step up in quality from previous opponents.
This is a good opportunity for Bills QB Josh Allen to get firing again, and he is backed to take it.
This is a good opportunity for Bills QB Josh Allen to get firing again, and he is backed to take it.
Buffalo -9.0
Spread
@-111.11 - 4 Units
25 SC no deposit & 250,000 GC
Use promo code NEWBONUS
Get 25 Stake Cash & 250,000 Gold Coins when you sign up with code NEWBONUS at Stake.us. USA only. Excludes certain States including NY,NV,ID, KY,WA. 18+ only. Terms and Conditions apply.
Over 54.0
Total Points
@-111.11 - 2 Units
25 SC no deposit & 250,000 GC
Use promo code NEWBONUS
Get 25 Stake Cash & 250,000 Gold Coins when you sign up with code NEWBONUS at Stake.us. USA only. Excludes certain States including NY,NV,ID, KY,WA. 18+ only. Terms and Conditions apply.
See also
- Pittsburgh Steelers at Indianapolis Colts Live Stream – How To Watch Live Online With Stake
- Green Bay Packers at Philadelphia Eagles Live Stream – How To Watch Live Online With Stake
- Pittsburgh Steelers at Indianapolis Colts Preview & Picks – NFL Monday Game To Be Low-Scoring
- Green Bay Packers at Philadelphia Eagles Preview & Picks – Eagles To Cover In NFL Sunday Showdown
- New England Patriots at Minnesota Vikings – Get Double Winnings With Stake’s NFL Thanksgiving Day Offer
- New York Giants at Dallas Cowboys – Get Double Winnings With Stake’s NFL Thanksgiving Day Offer
- Buffalo Bills at Detroit Lions – Get Double Winnings With Stake’s NFL Thanksgiving Day Offer
- New Orleans Saints at San Francisco 49ers Preview & Picks – In-Form 49ers To Cover In NFL Win
- Cincinnati Bengals at Tennessee Titans Preview & Picks – Titans To Cover As Home NFL Underdog
- New England Patriots at Minnesota Vikings Live Stream – How To Watch Live Online With Stake
- New England Patriots at Minnesota Vikings Preview & Picks – Vikings To Hit Back In NFL Thursday Game
- New York Giants at Dallas Cowboys Preview & Picks – Dallas To Cover In Crucial NFL Matchup
Upcoming Events
17 March 2026
MD Baltimore Co @ Howard Basketball
UMBC vs Howard Predictions & Picks – UMBC To Reach March Madness First Round
OKC Thunder @ ORL Magic Basketball
Oklahoma City Thunder at Orlando Magic Predictions & Picks – Magic To Cover As Home NBA Underdogs
18 March 2026
Texas @ NC State Basketball
Texas vs NC State Predictions & Picks – Texas To Take March Madness Matchup
BUF Sabres @ VGS Golden Knights Ice Hockey
Buffalo Sabres at Vegas Golden Knights Predictions & Picks – Sabres Backed For ‘Sin City’ Success In NHL
Champions League Tips - March 17-18 Soccer
Champions League Predictions & Tips - Round of Sixteen Preview
Prairie View A&M @ Lehigh Basketball
Prairie View A&M vs Lehigh Predictions & Picks – Back Panthers For March Madness Victory
Inter Miami vs Nashville Soccer
Inter Miami vs Nashville Predictions & Picks - Expect Goals In Champions Cup Clash
19 March 2026
Miami Ohio @ SMU Basketball
Miami OH vs SMU Predictions & Picks – Back Redhawks With Free Buckets In March Madness
20 March 2026
Michael Conlan vs Kevin Walsh Boxing
Michael Conlan vs Kevin Walsh Live Stream – How To Watch Live Online
21 March 2026
George Liddard vs Tyler Denny Boxing
George Liddard vs Tyler Denny Live Stream – How To Watch Live Online
22 March 2026
27 March 2026
2026 MLB World Series Betting Preview Baseball
2026 MLB World Series Odds – LA Dodgers Favourites For 3-Peat
28 March 2026
2026 UFL Betting Preview American Football
2026 UFL Championship Odds – Stallions Backed To Regain Spring American Football Crown
29 March 2026
04 April 2026
10 April 2026
23 April 2026
17 May 2026
Ronda Rousey vs Gina Carano UFC
Ronda Rousey vs Gina Carano Preview & Picks – Rousey To Tap Out Carano In Netflix Super-Fight
30 June 2026
NHL 2025/26 Betting Specials Ice Hockey
NHL Daily Pick ‘Em Game – Win Cash Prizes, Trips To NHL Games & More With BET99's Free-To-Play Competition
20 September 2026
Floyd Mayweather Jr vs Manny Pacquiao 2 Boxing
Floyd Mayweather Jr vs Manny Pacquiao 2 Preview & Picks – Mayweather To Repeat 2015 Victory
Poker EventsStarts in
MD Baltimore Co @ Howard
OKC Thunder @ ORL Magic
Texas @ NC State
BUF Sabres @ VGS Golden Knights
Champions League Tips - March 17-18
Prairie View A&M @ Lehigh
Inter Miami vs Nashville
Miami Ohio @ SMU
Michael Conlan vs Kevin Walsh
George Liddard vs Tyler Denny
Movsar Evloev vs Lerone Murphy
Carlos Adames vs Austin Williams
Latest News
-
Latest Odds -
NFL OddsSuper Bowl LXI Odds – Seattle Seahawks Favored For Back-To-Back NFL Crowns10 Feb 2026Read More
-
Back SeahawksSeattle Seahawks vs New England Patriots Preview & Picks – Seahawks To Win Super Bowl LX05 Feb 2026Read More
-
Super Bowl TipsSeattle Seahawks vs New England Patriots MVP Preview & Picks – Who Will Be Named Super Bowl LX MVP?05 Feb 2026Read More
-
NFL TipsSeattle Seahawks vs New England Patriots Preview & Picks – Who Will Score 1st Touchdown Of Super Bowl LX?05 Feb 2026Read More
