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Denver Broncos at Indianapolis Colts Preview & Picks – Broncos To Ride Run Game & Defense To NFL Win

leigh-copson
11 Sep 2025
leigh-copson
Leigh Copson 11 Sep 2025
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  • Denver Broncos at Indianapolis Colts picks for Sunday, September 14
  • Game is taking place at Lucas Oil Stadium
  • Preview, predictions, stats & form
(Getty Images)
    Denver Broncos at Indianapolis Colts Preview & Picks
  • Denver Broncos at Indianapolis Colts Preview & Picks
  • Head To Head
  • Denver Broncos Form
  • Indianapolis Colts Form

Denver Broncos at Indianapolis Colts Preview & Picks

Denver are tipped to bring Indianapolis back down to Earth on Sunday.

The Broncos can lean on a hugely-improved run game and a dominant defense that will pose a much tougher threat to Daniel Jones than the Dolphins did.

  • Denver won by 18 points when the teams met last December
  • The Under has cashed in 3 of the previous 4 meetings
  • The Under hit in Denver’s opening game of the season
  • The Under cashed in Indianapolis’ season-opening game

Head To Head

  • The all-time series is tied at 15-15
  • Denver Broncos won 31-13 when the two teams last met in December 2024

Denver Broncos Form

Denver head out on the road for the first time this season looking to back up an opening day win over Tennessee.

The Broncos ended an eight-year absence from the playoffs as they went 10-7 in 2024 to earn a place in the postseason.

Their stay proved to be a brief one though, as they were beaten blown out on the road by Buffalo in the Wildcard round, losing 31-7.

It was still a positive step forward for Denver though, after a string of losing seasons, and their quest for a return to the playoffs in 2025 got off to a successful start last weekend.

The Broncos shut down the Tennessee offense and dominated on the ground as they ran out 20-12 winners against the Titans.

Indianapolis Colts Form

Indianapolis enter this matchup looking to back up their opening-day demolition of Miami at Lucas Oil Stadium.

The Colts failed to make the postseason for the fourth straight year in 2024 as they finished 8-9 in the AFC South.

Consistency eluded them throughout the campaign as they strung together wins on just two occasions and had issues at quarterback.

Indianapolis attempted to solve that problem by bringing in former New York Giants QB Daniel Jones in the offseason, and he enjoyed a highly successful debut last weekend.

Jones went 22/29 for 272 yards and a touchdown, while also rushing for two more scores as the Colts blew out Miami, 33-8.

Verdict

Daniel Jones enjoyed a dream debut for the Colts, but this Denver defense can issue a reality check.

They can put the clamps on this Indy offense and ride the run game to a second win of the season.

Best Bet1: Denver -1.5 Spread @-111.11 at Stake.us - 4 Units
Best Bet2: Under 42.5 Total Points @-111.11 at Stake.us - 2 Units
Denver -1.5
Spread
@-111.11 - 4 Units
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Bet at Stake.us
Under 42.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us