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Indianapolis Colts at Kansas City Chiefs Preview & Picks – Colts To Cover As NFL Underdogs

leigh-copson
19 Nov 2025
leigh-copson
Leigh Copson 19 Nov 2025
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  • Indianapolis Colts at Kansas City Chiefs picks for Sunday, November 23
  • Game is taking place at Arrowhead Stadium
  • Preview, predictions, stats & form
(Getty Images)
    Indianapolis Colts at Kansas City Chiefs Preview & Picks
  • Indianapolis Colts at Kansas City Chiefs Preview & Picks
  • Head To Head
  • Indianapolis Colts Form
  • Kansas City Chiefs Form

Indianapolis Colts at Kansas City Chiefs Preview & Picks

Indianapolis are tipped to cover as a betting underdog at Arrowhead.

The Colts can lean on Jonathan Taylor against an underwhelming Chiefs run defense to help them chew up the clock and, at the very least, keep them to within a field goal.

  • Indianapolis Colts are 2-1-0 ATS as a betting underdog
  • Kansas City Chiefs have lost their previous 2 games
  • Kansas City Chiefs are 2-4-0 ATS in their 6 games as a single digit favorite
  • The Under has hit in each of Kansas City’s previous 5 games

Head To Head

  • Indianapolis Colts lead the all-time series 18-10
  • Indianapolis Colts won 20-17 when the two teams last met in September 2022

Indianapolis Colts Form

Indianapolis return from the bye week with an 8-2 record thanks to a victory in Germany last time out.

The Colts opened the season with a three-game win streak, beating Miami 33-8, Denver 29-28 and Tennessee 41-20.

Their perfect start was ended by a 27-20 defeat at the Los Angeles Rams, but they responded strongly with a four-game win streak.

Indianapolis blew out Las Vegas 40-6 at home, and backed that up with a 31-27 victory over Arizona, a 38-24 success at the Los Angeles Changers and a 38-14 win against Tennessee.

The Colts’ run was ended by a 27-20 loss at Pittsburgh, but they rebounded in Berlin with a 31-25 overtime win against Atlanta.

Kansas City Chiefs Form

Kansas City enter this matchup in desperate need of a victory, having now lost back-to-back games to slip to 5-5.

The Chiefs opened the season with a couple of defeats, losing 27-21 to the Los Angeles Chargers in Brazil before dropping the Super Bowl rematch with Philadelphia at home, 20-17.

They finally got off the mark with a 22-9 win at the New York Giants and backed it up with a 37-20 success against Baltimore, only to then suffer a 31-28 defeat in Jacksonville.

Kansas City responded to that loss with a three-game win streak at home, beating Detroit 30-17, Las Vegas 31-0 and Washington 28-7.

The Chiefs failed to keep that run going on the road though, as they fell to a 28-21 defeat in Buffalo before losing 22-19 at Denver.

Verdict

Indianapolis are fresh off the bye week and arguably boast the best player in the NFL right now in Johnathan Taylor.

The Colts can strap the offense on Taylor’s back and grind out the cover at Arrowhead.

Best Bet1: Indianapolis +3.5 Spread @-111.11 at Stake.us - 3 Units
Best Bet2: Under 49.5 Total Points @-111.11 at Stake.us - 3 Units
Indianapolis +3.5
Spread
@-111.11 - 3 Units
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Bet at Stake.us
Under 49.5
Total Points
@-111.11 - 3 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us