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Kansas City Chiefs at Buffalo Bills Preview & Picks – Takes Bills & Free Points In Huge NFL Showdown

leigh-copson
28 Oct 2025
leigh-copson
Leigh Copson 28 Oct 2025
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  • Kansas City Chiefs at Buffalo Bills picks for Sunday, November 2
  • Game is taking place at Highmark Stadium
  • Preview, predictions, stats & form
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    Kansas City Chiefs at Buffalo Bills Preview & Picks
  • Kansas City Chiefs at Buffalo Bills Preview & Picks
  • Head To Head
  • Kansas City Chiefs Form
  • Buffalo Bills Form

Kansas City Chiefs at Buffalo Bills Preview & Picks

Buffalo are tipped to cover as a slight underdog at home.

The recent regular season trend has been for Josh Allen and the Bills to get the better of Patrick Mahomes and KC, and given the Chiefs poor road record that trend may continue.

  • Buffalo Bills are 1-0-0 ATS as a betting underdog this season
  • Josh Allen is 4-1 in the regular season against Mahomes’ Chiefs
  • Kansas City Chiefs are 1-2 on the road so far this season
  • The Over has cashed in 6 of the previous 8 meetings

Head To Head

  • Buffalo Bills lead the all-time series 30-26-1
  • Buffalo Bills won 30-21 when the two teams last met in November 2024

Kansas City Chiefs Form

Kansas City head out on the road looking to extend a three-game win streak that has taken them to 5-3.

The Chiefs made a miserable start as they were beaten 27-21 by the Los Angeles Chargers in Brazil, and then lost 20-17 at home to Philadelphia in a rematch of last season’s Super Bowl.

They finally got off the mark in Week 3 with a 22-9 victory at the New York Giants, and backed it up a week later by beating Baltimore 37-20 at home.

Kansas City failed to make it three-in-a-row as they lost 31-28 at Jacksonville, but they have not lost since that night.

The Chiefs have rebounded with three straight wins at home, beating Detroit 30-17, Las Vegas 31-0 and Washington 28-7.

Buffalo Bills Form

Buffalo return home looking to build on last weekend’s win in Carolina, which snapped a two-game skid and improved their record to 5-2.

The Bills staged a sensational last-gasp fightback to beat Baltimore 41-40 on opening night, and they went on to win their first four games of the season.

They beat the New York Jets 30-10 on the road, before returning home to down Miami 31-21 and New Orleans 31-19.

Buffalo’s perfect start was finally ended by a surprise 23-20 loss to New England, and they then suffered another shock defeat as they were beaten 24-14 in Atlanta.

The Bills got back on track last weekend through, as they dominated the Panthers in a 40-9 victory in Carolina.

Verdict

Form can go out of the window when these two teams meet, but one trend has not.

Josh Allen vs Patrick Mahomes in the regular season usually leads to a Bills win, and Kansas City have been unconvincing on the road.

Best Bet1: Buffalo +1.5 Spread @-111.11 at Stake.us - 3 Units
Best Bet2: Under 52.5 Total Points @-111.11 at Stake.us - 3 Units
Buffalo +1.5
Spread
@-111.11 - 3 Units
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Bet at Stake.us
Under 52.5
Total Points
@-111.11 - 3 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us