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San Francisco 49ers at Houston Texans Preview & Picks – 49ers To Take Down Texans In NFL

leigh-copson
22 Oct 2025
leigh-copson
Leigh Copson 22 Oct 2025
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  • San Francisco 49ers at Houston Texans picks for Sunday, October 26
  • Game is taking place at NRG Stadium
  • Preview, predictions, stats & form
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    San Francisco 49ers at Houston Texans Preview & Picks
  • San Francisco 49ers at Houston Texans Preview & Picks
  • Head To Head
  • San Francisco 49ers Form
  • Houston Texans Form

San Francisco 49ers at Houston Texans Preview & Picks

San Francisco are tipped to cover as they win on the road in Houston.

The 49ers are dealing with a bunch of injuries, but they continue to find ways to get that done and they can lean on Christian McCaffrey and the defense at NRG Stadium.

  • San Francisco 49ers are 5-2 this season
  • San Francisco 49ers are 3-1-0 ATS on the road this season
  • Houston Texans are 0-4-0 ATS in their 4 defeats
  • The Under has cashed in 4 of Houston’s 6 games

Head To Head

  • San Francisco 49ers lead the all-time series 4-1
  • San Francisco 49ers won 23-7 when the two teams last met in January 2022

San Francisco 49ers Form

San Francisco head out on the road looking to win back-to-back games for the first time in over a month.

The 49ers made a flying start to the season as they won back-to-back games on the road, downing Seattle 17-13 and New Orleans 26-21.

They then won their home opener against Arizona, 16-15, before finally suffering their first defeat of the season in the form of a 26-21 loss to Jacksonville.

San Francisco rebounded with a 26-23 overtime victory at the Los Angeles Rams, but failed to follow that up as they lost 30-19 at Tampa Bay.

The 49ers did bounce back quickly from the loss though, as they beat Atlanta 20-10 at home last time out.

Houston Texans Form

Houston enter this matchup having seen their recent resurgence end with a defeat in Seattle.

The Texans kicked off the campaign with a 14-9 defeat at the Los Angeles Rams, and then dropped their home opener against Tampa Bay, 20-19.

Their losing start then reached three games with a 17-10 defeat in Jacksonville, before they finally got off the mark with a 26-0 shutout of Tennessee.

Houston backed that up with a 44-10 blowout of the Ravens in Baltimore before the bye week, but they failed to follow that up when they returned to action last Monday night.

The Texans visited Seattle for Monday Night Football and suffered a 27-19 defeat at the hands of the Seahawks.

Verdict

San Francisco remain short-handed, but they continue to keep themselves firmly in the playoff race.

They have won a bunch of games on the road too, so we like their chances against a Houston team coming off another loss and playing on a short week.

Best Bet1: San Francisco -1.5 Spread @-111.11 at Stake.us - 4 Units
Best Bet2: Under 41.5 Total Points @-111.11 at Stake.us - 2 Units
San Francisco -1.5
Spread
@-111.11 - 4 Units
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Bet at Stake.us
Under 41.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us