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21 Oct 2025
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Tennessee Titans at Indianapolis Colts Preview & Picks – Back Colts For Blowout NFL Win
- Tennessee Titans at Indianapolis Colts picks for Sunday, October 26
- Game is taking place at Lucas Oil Stadium
- Preview, predictions, stats & form
(Getty Images)
- Tennessee Titans at Indianapolis Colts Preview & Picks
- Head To Head
- Tennessee Titans Form
- Indianapolis Colts Form
Tennessee Titans at Indianapolis Colts Preview & Picks
Tennessee Titans at Indianapolis Colts Preview & Picks
Indianapolis are tipped to continue their red-hot form with a blowout win.
The Colts offense is firing on all cylinders and should have few issues piling up the points against this terrible Tennessee team.
- Indianapolis Colts are 5-1-0 ATS in their 6 victories
- Tennessee Titans are 1-5-0 ATS in their 6 losses
- Indianapolis Colts are 5-0-0 ATS in the last 5 meetings
- The Over has cashed in 4 of Indianapolis’ last 6 games
Head To Head
- Indianapolis Colts lead the all-time series 33-13-1
- Indianapolis Colts won 41-20 when the two teams last met on September 21
Tennessee Titans Form
Tennessee head to Indianapolis in terrible form, having suffered the sixth defeat of the season last time out.
The Titans began the campaign by winning just one of their first five games, resulting in Brian Callahan being the first head coach to be fired this season.
They were beaten 20-12 in Denver, 33-19 by the Los Angeles Rams, 41-20 by Indianapolis and 26-0 by Houston, before finally getting off the mark with a 22-21 win over Arizona.
Tennessee failed to build on that as they lost 20-13 in Las Vegas, leading to Callahan’s departure.
A change in head coach did not result in an immediate change of fortunes though, as the Titans were beaten 31-13 by New England last weekend.
Indianapolis Colts Form
Indianapolis boast a league-best 6-1 record thanks to last weekend’s victory on the road.
The Colts have been the surprise packed of the season so far, with Daniel Jones resurrecting his career with the franchise.
They opened with back-to-back home wins, beating Miami 33-8 and Denver 29-28, before heading out on the road to down Tennessee 41-20.
Indianapolis’ perfect start was then ended by a 27-20 loss at the Los Angeles Rams, but they issued an emphatic response to that setback.
The Colts blew out Las Vegas at home, 40-6, and then backed that up by beating Arizona 31-27 at home and the Los Angeles Chargers 38-24 on the road.
Verdict
This matchup pits the hottest team in the NFL against the worst team in the NFL.
Everything is pointing towards Indianapolis getting the job done here, and given just how bad Tennessee have been so far, we expect this to be a one-sided blowout.
Everything is pointing towards Indianapolis getting the job done here, and given just how bad Tennessee have been so far, we expect this to be a one-sided blowout.
Indianapolis -14.0
Spread
@-111.11 - 4 Units
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Over 47.0
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS
Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.
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