Premier League Predictions: April 21-22

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Ryan Allan 1 hour ago
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  • Brighton vs Chelsea - Home Win Tipped
  • Burnley vs Man City - Citizens to Blast Clarets
  • Bournemouth vs Leeds - BTTS/Over 2.5 Goals Backed
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Chelsea Head Coach Liam Rosenior (Getty Images)

Premier League Predictions: April 21st - April 22nd

A midweek round of Premier League action lies ahead, with three fixtures on the card set to impact both the title race and the battle for the European places, and we’ve got it covered at ExpertPicks.

Brighton vs Chelsea

Brighton welcome Chelsea to the Amex in Tuesday’s only Premier League fixture. With the Blues in freefall and the Seagulls enjoying another strong run of form, a home win offers plenty of value.

The hosts have won five and lost just one of their last seven Premier League matches. Chelsea, by contrast, have lost each of their last four league games and were also beaten in their previous three meetings with Brighton.

I expect a similar outcome this week.

Prediction 2-0
Best Bet: Brighton to Win

Burnley vs Manchester City

Manchester City take the momentum of their huge win against Arsenal on Sunday to Turf Moor in one of two Premier League matches on Wednesday. 

Pep Guardiola’s side have begun to find their best form at the right time of the season, and they should make light work of a now-doomed Burnley side. The Citizens won 11 of their last 13 domestic fixtures, including an impressive 3-0 win at Chelsea in their last road trip.

The Clarets collapsed to a 4-1 defeat at Nottingham Forest on Sunday, and a similarly heavy reversal seems inevitable on Tuesday. 

Prediction 0-3
Best Bet: Manchester City Over 2.5 Team Goals

Bournemouth vs Leeds

A potentially entertaining and high-scoring contest looks likely when in-form Bournemouth host Leeds on Wednesday.

The Cherries have enjoyed a superb run in 2026, remaining unbeaten in 13 Premier League matches since the turn of the year. Leeds have also been in strong form, losing only two of their last 11 fixtures.

With both sides impressive in the forward areas, I expect BTTS and over 2.5 goals to land at the Vitality Stadium.

Prediction 2-2
Best Bet: BTTS and Over 2.5 Goals

Verdict

Premier League preview for April 21st-22nd, 2026, featuring short previews and bettings tips for Brighton vs Chelsea, Burnley vs Manchester City, and Bournemouth vs Leeds.

Best Bet1: Brighton vs Chelsea Brghton Win @145.00 at Stake.com - 3 Units
Best Bet2: Burnley vs Man City Man City Over 2.5 Team Goals @-151.52 at Stake.com - 4 Units
Best Bet3: Bournemouth vs Leeds BTTS & Over 2.5 Goals @100.00 at Stake.com - 3 Units
Brighton vs Chelsea
Brghton Win
@145.00 - 3 Units
25 SC no deposit & 250,000 GC
Use promo code NEWBONUS

Get 25 Stake Cash & 250,000 Gold Coins when you sign up with code NEWBONUS at Stake.us. USA only. Excludes certain States including NY,NV,ID, KY,WA. 18+ only. Terms and Conditions apply.

Bet at Stake.com
Burnley vs Man City
Man City Over 2.5 Team Goals
@-151.52 - 4 Units
25 SC no deposit & 250,000 GC
Use promo code NEWBONUS

Get 25 Stake Cash & 250,000 Gold Coins when you sign up with code NEWBONUS at Stake.us. USA only. Excludes certain States including NY,NV,ID, KY,WA. 18+ only. Terms and Conditions apply.

Bet at Stake.com
Bournemouth vs Leeds
BTTS & Over 2.5 Goals
@100.00 - 3 Units
25 SC no deposit & 250,000 GC
Use promo code NEWBONUS

Get 25 Stake Cash & 250,000 Gold Coins when you sign up with code NEWBONUS at Stake.us. USA only. Excludes certain States including NY,NV,ID, KY,WA. 18+ only. Terms and Conditions apply.

Bet at Stake.com

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