Boston Red Sox at Cleveland Guardians Predictions & Picks – Guardians To Win MLB Series Opener

leigh-copson
29 May 2026
Leigh Copson 29 May 2026
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  • Boston Red Sox at Cleveland Guardians picks for Friday, May 29
  • Game is taking place at Progressive Field
  • Preview, predictions, stats & form
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Boston Red Sox at Cleveland Guardians Predictions & Picks

Cleveland are tipped to take the opening game of this home series.

Starter Slade Ceccioni has had his issues this season, but he has been solid at home despite one rough outing, and the Guardians are the team in better form.

  • Cleveland Guardians are 12-4 in their last 16 games
  • Cleveland have won 4 of the last 5 games Slade Ceccioni appeared in
  • Boston Red Sox are 1-5 in their previous 6 games
  • The Under has been cashed in 6 of Cleveland’s last 8 games

Head To Head

  • Cleveland Guardians lead the all-time series 1074-1013-8
  • Cleveland Guardians won 8-1 when the two teams last met in September 2025

Boston Red Sox Form

Boston head to Cleveland on the back of a rough run at home that saw them lose five times in six games.

DateOppositionW/LScore
May-17 at Atlanta Braves L 1-8
May-18 at Kansas City Royals W 3-1
May-19 at Kansas City Royals W 7-1
May-20 at Kansas City Royals W 4-3
May-22 vs Minnesota Twins L 6-8
May-23 vs Minnesota Twins L 2-4
May-24 vs Minnesota Twins L 5-6
May-26 vs Atlanta Braves L 6-7
May-27 vs Atlanta Braves W 8-0
May-28 vs Atlanta Braves L 2-10

Cleveland Guardians Form

Cleveland enter this series having bounced back from a couple of defeats with their 12th victory in their last 16 games.

DateOppositionW/LScore
May-18 at Detroit Tigers W 8-2
May-19 at Detroit Tigers W 4-3
May-20 at Detroit Tigers W 3-2
May-21 at Detroit Tigers W 3-1
May-22 at Philadelphia Phillies W 1-0
May-23 at Philadelphia Phillies L 0-3
May-24 at Philadelphia Phillies W 3-1
May-25 vs Washington Nationals L 2-10
May-26 vs Washington Nationals L 3-6
May-27 vs Washington Nationals W 3-2

Starting Pitchers

NameTeamRecordERAStrikeoutsInnings
Tyler Samaniego Boston Red Sox 0-2 1.04 13 17.1
Slade Cecconi Cleveland Guardians 3-5 5.18 47 57.1

Verdict

Slade Ceccioni’s numbers do not make for great reading, but he has delivered strong performances in two of his three home outings this season.

Cleveland’s form has been strong too despite a couple of recent defeats, so we are backing the Guardians here.

Best Bet1: Cleveland Win Moneyline @-120.48 at Stake.us - 4 Units
Best Bet2: Under 8.0 Total Runs @-116.28 at Stake.us - 2 Units
Cleveland Win
Moneyline
@-120.48 - 4 Units
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Bet at Stake.us
Under 8.0
Total Runs
@-116.28 - 2 Units
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Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us

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