2026 NFL Draft Odds – Fernando Mendoza Overwhelming Favorite To Be Number 1 Pick After Indiana Success
21 Jan 2026Read More
Arizona Cardinals at San Francisco 49ers Preview & Picks – 49ers To Clip Cardinals’ Wings In NFL Clash
- Arizona Cardinals at San Francisco 49ers picks for Sunday, September 21
- Game is taking place at Levi's Stadium
- Preview, predictions, stats & form
(Getty Images)
- Arizona Cardinals at San Francisco 49ers Preview & Picks
- Head To Head
- Arizona Cardinals Form
- San Francisco 49ers Form
Arizona Cardinals at San Francisco 49ers Preview & Picks
Arizona Cardinals at San Francisco 49ers Preview & Picks
San Francisco are tipped to retain their perfect record in their home opener.
Mac Jones has done a solid job as Brock Purdy’s stand-in, and the 49ers offense can lean on Christian McCaffrey and good defense to get the job done.
- San Francisco 49ers are 2-0-0 ATS this season
- San Francisco 49ers are 4-2-0 ATS in the previous 6 meetings
- Arizona Cardinals are 2-5 in their previous 7 road games
- The Under has cashed in 4 of San Francisco’s last 6 division games
Head To Head
- San Francisco 49ers lead the all-time series 36-31
- Arizona Cardinals won 47-24 when the two teams last met on January 5
Arizona Cardinals Form
Arizona head to San Francisco boasting a perfect record thanks to back-to-back wins to start the season.
The Cardinals went 8-9 to miss out on the postseason a year ago, but they have made a promising start as they look to end their playoff drought in 2025.
They kicked off the campaign on the road and ran out 20-13 winners over the Saints in New Orleans.
Arizona then backed up that victory in their home opener, as they fended off Carolina for a 27-22 win last weekend.
Through two games Cardinals quarterback Kyler Murray has thrown for 383 yards, three touchdowns and one interception, while also rushing for 70 yards.
San Francisco 49ers Form
San Francisco also enter this matchup with a 100% record, having opened the season with back-to-back wins on the road.
The 49ers appeared to suffer a Super Bowl hangover in 2024 as they won just six of their 17 games to miss out on the playoffs.
They have made a much more promising start to this season though, despite being sent out on the road in the first two weeks.
San Francisco kicked off the campaign in Seattle and were able to edge the division rival Seahawks, 17-13.
The 49ers then backed that up last weekend, as they travelled to New Orleans to take down the Saints, 26-21.
Verdict
Both teams are off to a perfect start and this is likely to be another close encounter between the pair.
San Francisco have home advantage and they also have McCaffrey and that defense, so we are siding with the Niners on Sunday night.
San Francisco have home advantage and they also have McCaffrey and that defense, so we are siding with the Niners on Sunday night.
San Francisco -1.5
Spread
@-111.11 - 4 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS
Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.
Under 43.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS
Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.
See also
- Detroit Lions at Baltimore Ravens Preview & Picks – Ravens To Cover In Monday NFL Victory
- Miami Dolphins at Buffalo Bills Preview & Picks – Bills To Down Dolphins In NFL Thursday Matchup
- Miami Dolphins at Buffalo Bills Boost – Get +200 Allen To Score & Over 48.5 Total Points
- Los Angeles Rams at Philadelphia Eagles Preview & Picks – Eagles To Win Big NFC Battle In NFL
- Denver Broncos at Los Angeles Chargers Preview & Picks – Chargers’ Perfect NFL Start To Continue
- Pittsburgh Steelers at New England Patriots Preview & Picks – Steelers To Bounce Back In NFL
- Kansas City Chiefs at New York Giants Preview & Picks – Chiefs To Get Off The Mark In NFL
- Dallas Cowboys at Chicago Bears Preview & Picks – Back Cowboys For ‘Windy City’ Win In NFL
Upcoming Events
10 March 2026
Frances Tiafoe vs Alexander Zverev Tennis
Frances Tiafoe vs Alexander Zverev Picks & Live Stream – Tiafoe to Push Zverev in Indian Wells
Learner Tien vs Alejandro Davidovich Fokina Tennis
Learner Tien vs Alejandro Davidovich Fokina Betting Picks & Live Stream – Long Match on the Cards in Indian Wells
11 March 2026
VGS Golden Knights @ DAL Stars Ice Hockey
Vegas Golden Knights at Dallas Stars Preview & Picks – Stars To Knock Off Knights Again In NHL
BOS Celtics @ SA Spurs Basketball
Boston Celtics at San Antonio Spurs Preview & Picks – Red-Hot Spurs To Turn Back Celtics In NBA
TOR Raptors @ HOU Rockets Basketball
Toronto Raptors at Houston Rockets Preview & Picks – Take Raptors & Free Buckets In NBA
Jannik Sinner vs Joao Fonseca Tennis
Joao Fonseca vs Jannik Sinner Picks & Live Stream – Early Set Battle Expected in Indian Wells
12 March 2026
14 March 2026
Jazza Dickens vs Anthony Cacace Boxing
Jazza Dickens vs Anthony Cacace Live Stream & Picks – How To Watch & Bet On World Title Fight Live Online
15 March 2026
Arnold Barboza Jr vs Kenneth Sims Jr Boxing
Arnold Barboza Jr vs Kenneth Sims Jr Live Stream – How To Watch Live Online
20 March 2026
Michael Conlan vs Kevin Walsh Boxing
Michael Conlan vs Kevin Walsh Live Stream – How To Watch Live Online
21 March 2026
George Liddard vs Tyler Denny Boxing
George Liddard vs Tyler Denny Live Stream – How To Watch Live Online
Movsar Evloev vs Lerone Murphy UFC
How To Watch UFC Fight Night: Evloev vs Murphy Live Stream From London
22 March 2026
27 March 2026
2026 MLB World Series Betting Preview Baseball
2026 MLB World Series Odds – LA Dodgers Favourites For 3-Peat
28 March 2026
2026 UFL Betting Preview American Football
2026 UFL Championship Odds – Stallions Backed To Regain Spring American Football Crown
29 March 2026
04 April 2026
23 April 2026
17 May 2026
Ronda Rousey vs Gina Carano UFC
Ronda Rousey vs Gina Carano Preview & Picks – Rousey To Tap Out Carano In Netflix Super-Fight
30 June 2026
NHL 2025/26 Betting Specials Ice Hockey
NHL Daily Pick ‘Em Game – Win Cash Prizes, Trips To NHL Games & More With BET99's Free-To-Play Competition
20 September 2026
Floyd Mayweather Jr vs Manny Pacquiao 2 Boxing
Floyd Mayweather Jr vs Manny Pacquiao 2 Preview & Picks – Mayweather To Repeat 2015 Victory
Poker EventsStarts in
Learner Tien vs Alejandro Davidovich Fokina
VGS Golden Knights @ DAL Stars
BOS Celtics @ SA Spurs
TOR Raptors @ HOU Rockets
Jannik Sinner vs Joao Fonseca
LIV Golf Singapore
The Players Championship
Jazza Dickens vs Anthony Cacace
Arnold Barboza Jr vs Kenneth Sims Jr
Josh Emmett vs Kevin Vallejos
Michael Conlan vs Kevin Walsh
George Liddard vs Tyler Denny
Latest News
-
Latest Odds -
NFL OddsSuper Bowl LXI Odds – Seattle Seahawks Favored For Back-To-Back NFL Crowns10 Feb 2026Read More
-
Back SeahawksSeattle Seahawks vs New England Patriots Preview & Picks – Seahawks To Win Super Bowl LX05 Feb 2026Read More
-
Super Bowl TipsSeattle Seahawks vs New England Patriots MVP Preview & Picks – Who Will Be Named Super Bowl LX MVP?05 Feb 2026Read More
-
NFL TipsSeattle Seahawks vs New England Patriots Preview & Picks – Who Will Score 1st Touchdown Of Super Bowl LX?05 Feb 2026Read More
