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Arizona Cardinals at San Francisco 49ers Preview & Picks – 49ers To Clip Cardinals’ Wings In NFL Clash
- Arizona Cardinals at San Francisco 49ers picks for Sunday, September 21
- Game is taking place at Levi's Stadium
- Preview, predictions, stats & form
(Getty Images)
- Arizona Cardinals at San Francisco 49ers Preview & Picks
- Head To Head
- Arizona Cardinals Form
- San Francisco 49ers Form
Arizona Cardinals at San Francisco 49ers Preview & Picks
Arizona Cardinals at San Francisco 49ers Preview & Picks
San Francisco are tipped to retain their perfect record in their home opener.
Mac Jones has done a solid job as Brock Purdy’s stand-in, and the 49ers offense can lean on Christian McCaffrey and good defense to get the job done.
- San Francisco 49ers are 2-0-0 ATS this season
- San Francisco 49ers are 4-2-0 ATS in the previous 6 meetings
- Arizona Cardinals are 2-5 in their previous 7 road games
- The Under has cashed in 4 of San Francisco’s last 6 division games
Head To Head
- San Francisco 49ers lead the all-time series 36-31
- Arizona Cardinals won 47-24 when the two teams last met on January 5
Arizona Cardinals Form
Arizona head to San Francisco boasting a perfect record thanks to back-to-back wins to start the season.
The Cardinals went 8-9 to miss out on the postseason a year ago, but they have made a promising start as they look to end their playoff drought in 2025.
They kicked off the campaign on the road and ran out 20-13 winners over the Saints in New Orleans.
Arizona then backed up that victory in their home opener, as they fended off Carolina for a 27-22 win last weekend.
Through two games Cardinals quarterback Kyler Murray has thrown for 383 yards, three touchdowns and one interception, while also rushing for 70 yards.
San Francisco 49ers Form
San Francisco also enter this matchup with a 100% record, having opened the season with back-to-back wins on the road.
The 49ers appeared to suffer a Super Bowl hangover in 2024 as they won just six of their 17 games to miss out on the playoffs.
They have made a much more promising start to this season though, despite being sent out on the road in the first two weeks.
San Francisco kicked off the campaign in Seattle and were able to edge the division rival Seahawks, 17-13.
The 49ers then backed that up last weekend, as they travelled to New Orleans to take down the Saints, 26-21.
Verdict
Both teams are off to a perfect start and this is likely to be another close encounter between the pair.
San Francisco have home advantage and they also have McCaffrey and that defense, so we are siding with the Niners on Sunday night.
San Francisco have home advantage and they also have McCaffrey and that defense, so we are siding with the Niners on Sunday night.
San Francisco -1.5
Spread
@-111.11 - 4 Units
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Under 43.5
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