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Indianapolis Colts at Jacksonville Jaguars Preview & Picks – Jaguars To Pounce On Colts In NFL

leigh-copson
04 Dec 2025
leigh-copson
Leigh Copson 04 Dec 2025
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  • Indianapolis Colts at Jacksonville Jaguars picks for Sunday, December 7
  • Game is taking place at EverBank Stadium
  • Preview, predictions, stats & form
(Getty Images)

Indianapolis Colts at Jacksonville Jaguars Preview & Picks

Jacksonville are tipped to win as a home underdog.

The Jaguars’ run defense can slow down Indianapolis’ ground attack, and it is clear for all to see that Colts QB Daniel Jones is massively hindered by an injury.

  • Jacksonville Jaguars are on a 3-game win streak
  • Indianapolis Colts have lost 3 of their last 5 games
  • The Under has hit in 5 of Jacksonville’s 6 home games
  • The Under has cashed in all 4 of Indianapolis’ defeats

Head To Head

  • Indianapolis Colts lead the all-time series 28-20
  • Indianapolis Colts won 26-23 in overtime when the two teams last met on January 5

Indianapolis Colts Form

Indianapolis head to Jacksonville in need of a victory, having now lost three of their last four games to fall to 8-4.

The Colts raced out of the blocks by winning their first three games, backing up home wins against Miami, 33-8, and Denver, 29-28, with a 41-20 victory at Tennessee.

They then responded to a 27-20 defeat at the Los Angeles Rams with back-to-back wins at home, beating Las Vegas 40-6 and Arizona 31-27.

Indianapolis made it four-in-a-row as they won 38-24 at the Los Angeles Chargers and 38-14 at home to Tennessee, only to see their run end with a 27-20 loss in Pittsburgh.

The Colts bounced back with a 31-25 overtime win against Atlanta, but they failed to back that up as they lost 23-20 in overtime at Kansas City and 20-16 at home to Houston.

Jacksonville Jaguars Form

Jacksonville enter this matchup having won three consecutive games to improve their record to 8-4.

The Jaguars opened with a 26-10 win over Carolina, and then rebounded from a 31-27 loss at Cincinnati by beating Houston 17-10, San Francisco 26-21 and Kansas City 31-28.

Their run was halted by a 20-12 defeat to Seattle, and that was followed by a 35-7 loss when they played host to the Los Angeles Rams.

Jacksonville avoided a third straight loss as they won 30-29 in overtime at Las Vegas, and they then bounced back from a 36-29 defeat at Houston with a 35-6 blowout of the Los Angeles Chargers.

The Jaguars have backed up that victory on the road, beating Arizona 27-24 in overtime and Tennessee 25-3 in regulation.

Verdict

Indianapolis are losing games, dealing with an injured quarterback, and now face a defense that can slow their run game.

The recipe is there for Jacksonville to win as a home underdog, and we are backing them to do just that.

Best Bet1: Jacksonville Win Moneyline @100.00 at Stake.us - 4 Units
Best Bet2: Under 47.5 Total Points @-111.11 at Stake.us - 2 Units
Jacksonville Win
Moneyline
@100.00 - 4 Units
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Bet at Stake.us
Under 47.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us