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Kansas City Chiefs at New York Giants Preview & Picks – Chiefs To Get Off The Mark In NFL

leigh-copson
16 Sep 2025
leigh-copson
Leigh Copson 16 Sep 2025
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  • Kansas City Chiefs at New York Giants picks for Sunday, September 21
  • Game is taking place at MetLife Stadium
  • Preview, predictions, stats & form
(Getty Images)
    Kansas City Chiefs at New York Giants Preview & Picks
  • Kansas City Chiefs at New York Giants Preview & Picks
  • Head To Head
  • Kansas City Chiefs Form
  • New York Giants Form

Kansas City Chiefs at New York Giants Preview & Picks

Kansas City are tipped to cover as they win for the first time this season.

The Chiefs defense can keep the New York offense in check, while the offense makes enough plays to come away with the win and cover.

  • Kansas City Chiefs are 23-5 on their last 28 games
  • New York Giants are 5-13-1 ATS in their last 19 games
  • The Under has cashed in 6 of Kansas City’s last 8 regular season games

Head To Head

  • New York Giants lead the all-time series 11-4
  • Kansas City Chiefs won 20-17 when the two teams last met in November 2021

Kansas City Chiefs Form

Kansas City head to New York in need of a victory, having opened the season with back-to-back defeats.

The Chiefs saw their quest for a historic three-peat end in disappointment as they were beaten by Philadelphia in last season’s Super Bowl, and they have so far struggled to rebound from that.

They kicked off the campaign with a trip to Brazil to face the Los Angeles Chargers, and suffered a 27-21 defeat at their hands of their division rivals.

Kansas City’s tough start then continued in their home opener as they took on Philadelphia in a rematch of last season’s Super Bowl.

The Chiefs again fell to defeat against the Eagles, with a 20-17 loss leaving them winless heading into Week 3.

New York Giants Form

New York enter their home opener having kicked off the 2025 season with back-to-back defeats to division rivals.

The Giants stood by head coach Brian Daboll despite a disappointing 2024 campaign, but they did make one major change in the offseason.

They brought in veteran quarterback Russell Wilson, but the former Seattle star is yet to lead the team to a victory.

New York began the campaign with a couple of road games against NFC East opposition, with the first of those ending in a 21-6 defeat to Washington.

The Giants offense produced a better showing in their second outing, but it was not enough as they lost 40-37 in overtime to Dallas last weekend.

Verdict

Kansas City definitely have some issues right now, but this is an ideal ‘get-right’ game for them.

New York’s defense just got gashed and the offense is unlikely to experience the same amount of success that they enjoyed against Dallas.

Best Bet1: Kansas City -5.5 Spread @-116.28 at Stake.us - 4 Units
Best Bet2: Under 44.5 Total Points @-111.11 at Stake.us - 2 Units
Kansas City -5.5
Spread
@-116.28 - 4 Units
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Bet at Stake.us
Under 44.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us