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Chicago Cubs at St Louis Cardinals Preview & Picks – Cardinals To Win 3rd Straight MLB Clash With Cubs

leigh-copson
25 Jun 2025
leigh-copson
Leigh Copson 25 Jun 2025
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  • Chicago Cubs at St Louis Cardinals picks for Wednesday, June 25
  • Game is taking place at Busch Stadium
  • Preview, predictions, stats & form
(Getty Images)
    Chicago Cubs at St Louis Cardinals Preview & Picks
  • Chicago Cubs at St Louis Cardinals Preview & Picks
  • Head To Head
  • Chicago Cubs Form
  • St Louis Cardinals Form

Chicago Cubs at St Louis Cardinals Preview & Picks

St Louis are tipped to win their third straight meeting with Chicago.

The Cardinals are the team in much better form heading into this matchup, and they are facing a Cubs starting pitcher who is yet to win on the road this season.

  • St Louis Cardinals are 8-2 in their last 10 games
  • Chicago Cubs are 1-5 in their previous 6 games
  • Chicago pitcher Matthew Boyd is 0-3 with a 3.22 ERA on the road
  • The Over has cashed in 8 of the previous 9 meetings

Head To Head

  • Chicago Cubs lead the all-time series 1276-1224-19
  • St Louis Cardinals won 8-7 when the two teams last met on June 24

Chicago Cubs Form

Chicago went into this road trip having been on an inconsistent run over the past couple of weeks.

The Cubs enjoyed a winning homecoming after a long road trip, beating Pittsburgh 3-2, but they failed to back that up as they lost the next meeting 2-1.

They rallied to take the next two games in the series though, beating the Pirates 2-1 and 3-2, and they then made it three-in-a-row as they downed Milwaukee, 5-4.

Chicago were unable to maintain that momentum however, losing the second game against the Brewers, 8-7.

The Cubs then hosted Seattle and sandwiched a 10-7 victory with 9-4 and 14-6 defeats to the Mariners. 

St Louis Cardinals Form

St Louis entered this series on the back of a defeat, but on a good run of form with six wins in their previous eight games.

The Cardinals endured a bad run earlier this month as they lost six straight games, before finally stopping the rot with an 8-5 win in Milwaukee.

They failed to follow that up as they lost the next meeting with the Brewers, 3-2, although they did rally on the road to wrap up that trip in positive form.

St Louis travelled to Chicago where they were able to sweep the White Sox, winning 12-2, 5-4 and 7-6.

The Cardinals then won back-to-back home games against Cincinnati, 6-1 and 6-5, before dropping the series finale to the Reds, 4-1.

Verdict

Chicago are on a rough run of form and are starting a pitcher that is yet to register a win on the road.

That spells trouble against an in-form St Louis team that has already beaten them twice this week, so give us the Cardinals in this one.

Best Bet1: St Louis Win Moneyline @115.00 at Stake.us - 3 Units
Best Bet2: Over 9.0 Total Runs @100.00 at Stake.us - 3 Units
St Louis Win
Moneyline
@115.00 - 3 Units
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Bet at Stake.us
Over 9.0
Total Runs
@100.00 - 3 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us