Cleveland Guardians at Chicago White Sox Predictions & Picks – Guardians To Continue White Sox Dominance In MLB

leigh-copson
2 hours ago
Leigh Copson 2 hours ago
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  • Cleveland Guardians at Chicago White Sox picks for Monday, June 22
  • Game is taking place at Guaranteed Rate Field
  • Preview, predictions, stats & form
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Cleveland Guardians at Chicago White Sox Predictions & Picks

Cleveland are tipped to bounce back from last night’s defeat in Houston.

The Guardians have spluttered offensively over the past couple of weeks, but they can get back on track against a White Sox starter who has struggled at times this season.

  • Cleveland Guardians are 8-2 in the previous 10 meetings
  • Cleveland Guardians are 5-2 in the last 7 meetings in Chicago
  • Chicago White Sox are 1-5 in their previous 6 games
  • The Under has cashed in each of the last 3 meetings

Head To Head

  • Cleveland Guardians lead the all-time series 1135-1131-17
  • Cleveland Guardians won 3-2 when the two teams last met in September 2025

Cleveland Guardians Form

Cleveland enter this game in underwhelming form, having just suffered their eighth defeat in their last 12 games.

DateOppositionW/LScore
Jun-09 vs New York Yankees L 2-3
Jun-10 vs New York Yankees L 4-8
Jun-12 vs Detroit Tigers W 3-2
Jun-13 vs Detroit Tigers W 3-1
Jun-16 at Milwaukee Brewers L 1-2
Jun-17 at Milwaukee Brewers L 4-9
Jun-18 at Milwaukee Brewers W 4-2
Jun-19 at Houston Astros L 3-9
Jun-20 at Houston Astros W 8-1
Jun-21 at Houston Astros L 1-2

Chicago White Sox Form

Chicago return home on a poor run of form, having been swept in Detroit and having now lost six of their last eight games.

DateOppositionW/LScore
Jun-10 vs Atlanta Braves W 2-1
Jun-12 vs Los Angeles Dodgers W 8-2
Jun-13 vs Los Angeles Dodgers L 1-7
Jun-14 vs Los Angeles Dodgers W 6-4
Jun-16 at New York Yankees L 2-12
Jun-17 at New York Yankees L 5-10
Jun-18 at New York Yankees W 5-1
Jun-19 at Detroit Tigers L 3-4
Jun-20 at Detroit Tigers L 1-4
Jun-21 at Detroit Tigers L 4-5 W/O

Starting Pitchers

PlayerTeamRecordERAStrikeoutsInnings
Gavin Williams Cleveland Guardians 9-4 3.83 103 91.2
Anthony Kay Chicago White Sox 6-2 4.61 55 70.1

Verdict

Both teams are in rough form, but Cleveland have an opportunity to get their offense going here.

The Guardians have dominated the White Sox in recent times, and that dominance can continue in the series opener.

Best Bet1: Cleveland Win Moneyline @-120.48 at Stake.us - 4 Units
Best Bet2: Under 8.0 Total Points @-125.00 at Stake.us - 2 Units
Cleveland Win
Moneyline
@-120.48 - 4 Units
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Bet at Stake.us
Under 8.0
Total Points
@-125.00 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us

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