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San Diego Padres at Chicago Cubs Preview & Picks – Cubs To Draw 1st Blood In MLB Wild Card

leigh-copson
30 Sep 2025
leigh-copson
Leigh Copson 30 Sep 2025
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  • San Diego Padres at Chicago Cubs picks for Tuesday, September 30
  • Wild Card Game 1 is taking place at Wrigley Field
  • Preview, predictions, stats & form
(Getty Images)
    San Diego Padres at Chicago Cubs Preview & Picks
  • San Diego Padres at Chicago Cubs Preview & Picks
  • Head To Head
  • San Diego Padres Form
  • Chicago Cubs Form

San Diego Padres at Chicago Cubs Preview & Picks

Chicago are tipped to take the opening game of this Wild Card series.

The Cubs' recent record against San Diego is rough, but they do have home advantage and not only have the Padres struggled on the road, starter Nick Pivetta has had problems at Wrigley Field.

  • Chicago Cubs are 6-3 in their last 9 home games
  • San Diego Padres are 6-11 in their last 17 road games
  • Nick Pivetta gave up 6 hits & 3 runs in just 3 innings in Chicago in April
  • The Over has cashed in 3 of the previous 5 meetings

Head To Head

  • Chicago Cubs lead the all-time series 287-242
  • San Diego Padres won 4-2 when the two teams last met on April 16

San Diego Padres Form

San Diego enter the postseason having put together a 90-72 record to finish second in the NL West.

The Padres ended the regular season on a strong run of form as they won seven of their final eight games.

They began this strong sequence on the road as they rebounded from road losses to the New York Mets and Chicago White Sox with 7-3 and 3-2 wins over the Sox.

San Diego then built on that at home as they beat Milwaukee 5-4 and 7-0, before dropping the series finale 3-1.

The Padres rebounded immediately from that loss though, wrapping up the regular season with a series sweep of Arizona thanks to 7-4, 5-1 and 12-4 victories.

Chicago Cubs Form

Chicago booked their place in the playoffs by compiling a 92-70 record to finish second in the NL Central.

The Cubs blew hot and cold over the final few weeks of the regular season, costing them an opportunity to win the division.

They won seven times in an eight-game spell earlier in September, with a victory in Pittsburgh during that run securing postseason baseball.

Chicago went cold immediately after that though as they lost five straight, and they then failed to build on a 10-3 win over the New York Mets as they lost the series finale 8-5.

The Cubs bounced back at home to St Louis however, as they swept the Cardinals thanks to 12-1, 7-3 and 2-0 wins to end the regular season.

Verdict

Chicago have dropped three of the last four against San Diego, but two of those losses were on the road.

The Cubs have been solid at home and the Padres have been struggling on their travels, so we are leaning towards the hosts in this one.

Best Bet1: Chicago Win Moneyline @-111.11 at Stake.us - 4 Units
Best Bet2: Over 7.0 Total Runs @-125.00 at Stake.us - 2 Units
Chicago Win
Moneyline
@-111.11 - 4 Units
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Bet at Stake.us
Over 7.0
Total Runs
@-125.00 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us