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Louisville vs Toledo Preview & Picks – Cardinals To Cover In Boca Raton Bowl Victory

leigh-copson
11 Dec 2025
leigh-copson
Leigh Copson 11 Dec 2025
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  • Louisville vs Toledo picks for Tuesday, December 23
  • Boca Raton Bowl is taking place at Flagler Credit Union Stadium in Boca Raton, Florida
  • Preview, predictions, stats & form
(Getty Images)

Louisville vs Toledo Preview & Picks

Louisville are tipped to cover as they claim the Boca Raton Bowl.

The Cardinals’ conference quest fell apart down the stretch, but the offense erupted once again in their regular season finale and can hang enough points on a solid Rockets defense.

  • Louisville went 3-1 in their 4 regular season road games
  • Toledo went 2-4 in their 6 road games during the regular season
  • The Under cashed in 5 of Toledo’s 6 road games
  • The Under has hit in 6 of Louisville’s last 8 games

Head To Head

  • Louisville lead the all-time series 5-3
  • Louisville won 31-6 when the two teams last met in September 1981

Louisville Form

Louisville’s late season collapse cost them a place in the ACC Championship and forced them to settle for an 8-4 record.

The Cardinals kicked off the season with three non-conference wins, before opening their ACC campaign with a 34-27 win at Pitt.

They failed to build on that a week later as they lost 30-27 to Virginia, but they rebounded in sensational fashion as they went out on the road to upset a number two ranked Miami team, 24-21.

Louisville backed that up by beat8ing Boston College 38-24 and Virginia Tech 28-16, but their season fell apart after that as they lost 29-26 to Cal, 20-19 to Clemson and 38-6 at SMU.

The Cardinals did at least finish the regular season on a positive note, shutting out Kentucky in a 41-0 victory.

Toledo Form

Toledo wrapped up the regular season with a four-game win streak that propelled them to an 8-4 record.

The Rockets rebounded from an opening day loss to Kentucky with a couple of non-conference wins, but struggled for consistency early in their MAC schedule.

They rebounded from a 14-13 loss at Western Michigan with a 45-3 demolition of Akron, and then responded to a 29-23 loss at Bowling Green with a 45-10 victory over Kent State.

Toledo again failed to follow up a win, this time losing a non-conference game, but when they returned to MAC duty they did not taste another defeat.

The Rockets reeled of four consecutive wins to close out the regular season, beating Northern Illinois 42-3, Miami Ohio 24-3, Ball State 38-9 and Central Michigan 21-3.

Verdict

Toledo are the team in better form, but they have lost their head coach and defensive co-ordinator.

That spell’s trouble against Jeff Brohm’s offense, so we expect Louisville to win this game and cover the spread.

Best Bet1: Louisville -7.5 Spread @-111.11 at Stake.us - 4 Units
Best Bet2: Under 44.5 Total Points @-111.11 at Stake.us - 2 Units
Louisville -7.5
Spread
@-111.11 - 4 Units
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Bet at Stake.us
Under 44.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us