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Buffalo Bills at New England Patriots Preview & Picks – Bills To Avenge October NFL Defeat To Patriots

leigh-copson
09 Dec 2025
leigh-copson
Leigh Copson 09 Dec 2025
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  • Buffalo Bills at New England Patriots picks for Sunday, December 14
  • Game is taking place at Gillette Stadium
  • Preview, predictions, stats & form
(Getty Images)

Buffalo Bills at New England Patriots Preview & Picks

Buffalo are tipped to avenge their October defeat to the Patriots.

Josh Allen has been playing at an MVP level, and that bodes well for the Bills as long as they cut out the penalties that hurt them in the first meeting.

  • Buffalo Bills are 5-2 in their last 7 games
  • Both of New England’s defeats this season came at home
  • The Under cashed when the two teams last met in October
  • The Under has hit in 5 of Buffalo’s 6 road games this season 

Head To Head

  • New England Patriots lead the all-time series 80-51-1
  • New England Patriots won 23-20 when the two teams last met on October 5

Buffalo Bills Form

Buffalo head out on the road having won five of their last seven games, and each of the last two, to improve to 9-4.

The Bills enjoyed a fast start to the season as they won their first four games, and then rebounded from a couple of defeats with back-to-back wins to sit 6-2 in early November.

They struggled for consistency after that though, having to bounce back from a 30-13 upset loss at Miami with a 44-32 victory over Tampa Bay.

Buffalo then failed to follow up that victory as they lost 23-19 at Houston, only to respond with a 26-7 victory in Pittsburgh.

This time the Bills managed to string together wins, as they returned home to down Cincinnati 39-34 last weekend.

New England Patriots Form

New England enter this matchup as the hottest team in the NFL, having won 10 straight games to reach 11-2.

The Patriots dropped two of their first three, before kicking off this red-hot run with a 42-13 victory when they hosted Carolina.

They then went out on the road to win three straight games, beating Buffalo 23-20, New Orleans 23-19 and Tennessee 31-13.

New England won the next two at home, beating Cleveland 32-13 and Atlanta 24-23, before following up a 28-23 success at Tampa with a 27-14 victory over the New York Jets.

The Patriots’ tear then reached 10 games as they won 26-20 in Cincinnati, before beating the New York Giants 33-15 at home.

Verdict

New England are red-hot right now, but Buffalo have just scored a couple of big wins with Josh Allen in outstanding form.

The Bills simply have to have this if they want to win the division, and we expect them to get the job done.

Best Bet1: Buffalo -1.5 Spread @-111.11 at Stake.us - 4 Units
Best Bet2: Under 49.5 Total Points @-111.11 at Stake.us - 2 Units
Buffalo -1.5
Spread
@-111.11 - 4 Units
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Bet at Stake.us
Under 49.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us