Betting

San Francisco 49ers at Arizona Cardinals Preview & Picks – 49ers To Win Key Division Clash In NFL

leigh-copson
12 Nov 2025
leigh-copson
Leigh Copson 12 Nov 2025
Share this article
Or copy link
  • San Francisco 49ers at Arizona Cardinals picks for Sunday, November 16
  • Game is taking place at State Farm Stadium
  • Preview, predictions, stats & form
(Getty Images)
    San Francisco 49ers at Arizona Cardinals Preview & Picks
  • San Francisco 49ers at Arizona Cardinals Preview & Picks
  • Head To Head
  • San Francisco 49ers Form
  • Arizona Cardinals Form

San Francisco 49ers at Arizona Cardinals Preview & Picks

San Francisco are tipped to cover as they take down an NFC West rival.

The 49ers should have few issues generating offense in this one, while an injury-hit defense can take advantage of a Cardinals offense featuring a bunch of backups.

  • San Francisco 49ers are 4-2 on the road
  • San Francisco 49ers are 4-0-0 ATS in their 4 road wins
  • Arizona Cardinals are 1-6 in their previous 7 games
  • The Under cashed when the two teams last met on September 21

Head To Head

  • San Francisco 49ers lead the all-time series 37-31
  • San Francisco 49ers won 16-15 when the two teams last met on September 21

San Francisco 49ers Form

San Francisco head to Arizona on an inconsistent run of form that has left them with a 6-4 record.

The 49ers made a fast start to the season as they reeled off three consecutive wins, beating Seattle 17-13 and New Orleans 26-21 on the road, before returning home to down Arizona 16-15.

Their perfect start was ended by a 28-21 loss to Jacksonville, but they rebounded immediately with a 26-23 overtime win at the Los Angeles Rams.

San Francisco then had to respond to a 30-19 defeat at Tampa Bay with a 20-10 victory over Atlanta, only to head to Houston for a surprise 26-15 loss.

The 49ers again bounced back quickly from a loss, winning 34-24 at the New York Giants, but they again failed to follow up a victory as they lost 42-26 at home to the Los Angeles Rams.

Arizona Cardinals Form

Arizona enter this matchup on a miserable run of form, having lost six of their last seven games to fall to 3-6.

The Cardinals opened the season with back-to-back wins, beating New Orleans 20-13 and Carolina 27-22, but it has been largely all downhill since then.

Their perfect start was ended by a 16-15 loss in San Francisco, and they then suffered back-to-back defeats at home as they lost 23-20 to Seattle and 22-21 to Tennessee.

Arizona’s skid continued as they lost 31-27 at Indianapolis and 27-23 at home to Green Bay, before they finally snapped the skid with a 27-17 upset of Dallas on the road.

The Cardinals were immediately brought back down to Earth though, as they lost 44-22 in Seattle last weekend.

Verdict

San Francisco could not have asked for a much better matchup to have after last week’s loss.

Arizona’s roster is ravaged by injuries and the losses are piling up, so we are backing the 49ers to bounce back on the road.

Best Bet1: San Francisco -3.0 Spread @-111.11 at Stake.us - 4 Units
Best Bet2: Under 48.5 Total Points @-111.11 at Stake.us - 2 Units
San Francisco -3.0
Spread
@-111.11 - 4 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us
Under 48.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us