Boston Bruins at Buffalo Sabres Predictions & Picks – Sabres To Increase Lead In NHL Playoffs Series

leigh-copson
20 Apr 2026
Leigh Copson 20 Apr 2026
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  • Boston Bruins at Buffalo Sabres picks for Tuesday, April 21
  • Game is taking place at KeyBank Center
  • Preview, predictions, stats & form
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Boston Bruins at Buffalo Sabres Predictions & Picks

Buffalo are tipped to make it back-to-back home wins to start this series.

The Sabres enter this matchup having been in solid form at home in recent weeks, while Boston have been piling up defeats on the road.

  • Buffalo Sabres are 10-4 in their last 14 home games
  • Boston Bruins are 1-5 in their previous 6 road games
  • The Over has cashed in 3 of the last 4 meetings this season

Head To Head

  • Boston Bruins lead the all-time series 187-139-43
  • Buffalo Sabres won 4-3 when the two teams last met on April 19

Boston Bruins Form

Boston enter the second game of this series trailing 1-0, having lost for the sixth time in eight games last time out.

DateOppositionW/LScore
Mar-29 at Columbus Blue Jackets W 4-3
Mar-31 vs Dallas Stars W 6-3
Apr-02 at Florida Panthers L 1-2
Apr-04 at Tampa Bay Lightning L 1-3
Apr-05 at Philadelphia Flyers L 1-2 OT
Apr-07 at Carolina Hurricanes L 5-6 OT
Apr-11 vs Tampa Bay Lightning L 1-2
Apr-12 at Columbus Blue Jackets W 3-2
Apr-14 vs New Jersey Devils W 4-0
Apr-19 at Buffalo Sabres L 3-4

Buffalo Sabres Form

Buffalo come into the second game of this series having taken a 1-0 lead thanks to their seventh win in 10 games, and their 10th victory in their last 14 at home.

DateOppositionW/LScore
Mar-28 vs Seattle Kraken W 3-2 SO
Mar-31 vs New York Islanders W 04-Mar
Apr-02 at Ottawa Senators L 1-4
Apr-04 at Washington Capitals L 2-6
Apr-06 vs Tampa Bay Lightning W 4-2
Apr-08 at New York Rangers W 5-3
Apr-09 vs Columbus Blue Jackets W 5-0
Apr-13 at Chicago Blackhawks W 5-1
Apr-15 vs Dallas Stars L 3-4 SO
Apr-19 vs Boston Bruins W 4-3

Verdict

Buffalo did not run away with Game 1, but they did get the job done on Sunday.

That continued a great run of home form for the Sabres and a rough run on the road for Boston, so give us the hosts in this one.

Best Bet1: Buffalo Win 3-Way Moneyline @-111.11 at Stake.us - 4 Units
Best Bet2: Over 6.0 Total Goals @-120.48 at Stake.us - 2 Units
Buffalo Win
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Bet at Stake.us
Over 6.0
Total Goals
@-120.48 - 2 Units
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Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us

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20 September 2026