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Seattle Mariners at Houston Astros Preview & Picks – Back Astros In MLB Series Opener

By Leigh Copson

22 May 2025

Leigh Copson 22 May 2025

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Seattle Mariners at Houston Astros picks for Thursday, May 22
Game is taking place at Minute Maid Park
Preview, predictions, stats & form

(Getty Images)

Seattle Mariners at Houston Astros Preview & Picks

Seattle Mariners at Houston Astros Preview & Picks
Head To Head
Seattle Mariners Form
Houston Astros Form

Seattle Mariners at Houston Astros Preview & Picks

Houston are tipped to win the opening game of this series.

The Astros can beat up on Seattle starter George Kirby, who is returning from IL and had a rough time in Triple A baseball during his rehab starts.

Houston Astros are 6-2 in their last 8 games
Houston Astros are 12-4 in their last 16 home games
Seattle pitcher George Kirby had a 7.20 ERA in Triple A
The Over has cashed in each of Lance McCullers Jr’s last 3 starts for Houston

Head To Head

Houston Astros lead the all-time series 131-91
Seattle Mariners won 7-6 when the two teams last met on April 9

Seattle Mariners Form

Seattle head to Houston having enjoyed some good form on this road trip so far, winning five of their six games.

The Mariners went out on the road on the back of a rough sequence at home that saw them lose five times in six games.

They got off to a strong start on this trip though, as they swept the Padres in a three-game series in San Diego.

Seattle reeled off 5-1, 4-1 and 6-1 victories, before making the long trip to Chicago for a three-game showdown with the White Sox.

The Mariners took the series opener 5-1, and then rebounded from a 1-0 defeat with a 6-5 success in the series finale.

Houston Astros Form

Houston return home after a mixed road trip that saw them go 3-4 across their seven games.

The Astros went into that trip on the back of a successful stint at home that saw them win five times in seven games.

They made a losing start in Texas though, falling 1-0, and then failed to build on a 6-3 victory over the Rangers as they lost the next meeting 5-1.

Houston settled for a split of that series as they won the finale 4-3, and they were able to back that up with a 4-3 victory at Tampa Bay.

The Astros have not won since however, suffered 3-2 and 8-4 defeats at the hands of the Rays.

Verdict

SEA Mariners @ HOU Astros

Houston are back home where they have been in strong form in recent weeks.

They are also coming up against a struggling pitcher, so we are backing the Astros to come away with the win in what could be a high-scoring game.

Houston Win

Moneyline

@120.00 - 3 Units

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Total Runs

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