Seattle Mariners at San Diego Padres Predictions & Picks – Padres To Win 8th Straight MLB Matchup

leigh-copson
16 Apr 2026
Leigh Copson 16 Apr 2026
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  • Seattle Mariners at San Diego Padres picks for Thursday, April 16
  • Game is taking place at Petco Park
  • Preview, predictions, stats & form
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Seattle Mariners at San Diego Padres Predictions & Picks

San Diego are tipped to complete a series sweep of San Diego.

The Padres are in red-hot form heading into this matchup and can beat up on struggling Mariners starter Luis Castillo.

  • San Diego Padres are on a 7-game win streak
  • Seattle Mariners are 1-7 on the road this season
  • Seattle starter Luis Castillo has a 6.92 ERA after 3 starts
  • The two starting pitchers have a combined ERA of 11.89

Head To Head

  • Seattle Mariners lead the all-time series 73-66
  • San Diego Padres won 7-6 when the two teams last met on April 15

Seattle Mariners Form

Seattle enter the final game of this road series having lost back-to-back outings to fall to 8-11.

Date Opposition W/L Score
Apr-05 at Los Angeles Angels L 7-8 W/O
Apr-06 at Texas Rangers L 1-2
Apr-07 at Texas Rangers L 2-3
Apr-08 at Texas Rangers L 0-3
Apr-10 vs Houston Astros W 9-6
Apr-11 vs Houston Astros W 8-7 W/O
Apr-12 vs Houston Astros W 6-1
Apr-13 vs Houston Astros W 6-2
Apr-14 at San Diego Padres L 1-4
Apr-15 at San Diego Padres L 6-7 W/O

San Diego Padres Form

San Diego come into this game as one of MLB’s form teams, having now won seven straight games to surge to 12-6.

DateOppositionW/LScore
Apr-05 at Boston Red Sox W 8-6
Apr-06 at Pittsburgh Pirates W 5-0
Apr-07 at Pittsburgh Pirates L 1-7
Apr-08 at Pittsburgh Pirates W 8-2
Apr-09 vs Colorado Rockies W 7-3 W/O
Apr-10 vs Colorado Rockies W 5-2 W/O
Apr-11 vs Colorado Rockies W 9-5
Apr-12 vs Colorado Rockies W 7-2
Apr-14 vs Seattle Mariners W 4-1
Apr-15 vs Seattle Mariners W 7-6 W/O

Starting Pitchers

PlayerTeamRecordERAStrikeoutsInnings
Luis Castillo Seattle Mariners 0-0 6.92 14 13.0
Walker Buehler San Diego Padres 0-1 4.97 11 12.2

Verdict

San Diego are on a red-hot run while Seattle have lost seven straight on the road.

So with struggling Castillo getting the start for the Mariners here, we are not expecting either of those trends to end tonight.

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Best Bet2: Over 8.0 Total Runs @-111.11 at Stake.us - 2 Units
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