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San Francisco 49ers at Los Angeles Rams Preview & Picks – Back Rams For Thursday NFL Success

leigh-copson
30 Sep 2025
leigh-copson
Leigh Copson 30 Sep 2025
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  • San Francisco 49ers at Los Angeles Rams picks for Thursday, October 2
  • Game is taking place at SoFi Stadium
  • Preview, predictions, stats & form
(Getty Images)
    San Francisco 49ers at Los Angeles Rams Preview & Picks
  • San Francisco 49ers at Los Angeles Rams Preview & Picks
  • Head To Head
  • San Francisco 49ers Form
  • Los Angeles Rams Form

San Francisco 49ers at Los Angeles Rams Preview & Picks

Los Angeles are tipped to cover as they win this Thursday night clash of NFC West rivals.

The Rams’ offense has been rolling in recent weeks, and this tough and talented defense can make some key stops to deliver the victory.

  • Los Angeles Rams are 3-0-0 ATS in their wins this season
  • Los Angeles Rams have won each of the last 3 meetings with San Francisco
  • San Francisco 49ers just lost for the 1st time this season
  • The Over has cashed in 4 of the last 5 meetings

Head To Head

  • San Francisco 49ers lead the all-time series 78-71-3
  • Los Angeles Rams won 12-6 when the two teams last met in December 2024

San Francisco 49ers Form

San Francisco enter this short week looking to rebound from their first defeat of the season.

The 49ers entered the campaign with Super Bowl ambitions and got off to a strong start as they won their first three games.

The first two of those victories came on the road as they beat division rivals Seattle, 17-13, and then downed New Orleans, 26-21.

San Francisco then made it three-in-a-row in their home opener as they beat NFC West foes Arizona, 16-15, despite the absence of starting quarterback Brock Purdy.

Purdy returned last weekend, but he struggled as the 49ers’ perfect start as ended by a 26-21 defeat to Jacksonville.

Los Angeles Rams Form

Los Angeles go into this matchup having rebounded from their first defeat of the season to improve to 3-1.

Like their opponents on Thursday, the Rams also entered the 2025 campaign with serious ambitions of lifting the Vince Lombardi Trophy.

They got off to a solid start as they won back-to-back games against AFC South teams, beating Houston 14-9 at home and Tennessee 33-19 on the road.

Los Angeles failed to make it three-in-a-row as they lost 33-26 at defending champions Philadelphia, but they were able to issue a swift response.

The Rams returned home last weekend to beat previously undefeated Indianapolis, 27-20.

Verdict

Both teams are off to 3-1 starts, but it is the Rams who are the more tempting pick.

Los Angeles have looked sharp on both sides of the football and just knocked off an in-form Indianapolis group, so we are backing them on a short week at home.

Best Bet1: LA Rams -5.5 Spread @-111.11 at Stake.us - 4 Units
Best Bet2: Over 46.5 Total Points @-111.11 at Stake.us - 2 Units
LA Rams -5.5
Spread
@-111.11 - 4 Units
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Bet at Stake.us
Over 46.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS

Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.

Bet at Stake.us