Carolina Panthers at Arizona Cardinals Predictions & Picks – Over To Hit In NFL Hall Of Fame Game
31 Jul 2026Read More
Jacksonville Jaguars at Buffalo Bills Preview & Picks – Bills To Stay Perfect With 3rd NFL Win
- Jacksonville Jaguars at Buffalo Bills picks for Monday, September 23
- Game is taking place at Highmark Stadium in Buffalo
- Preview, predictions, stats & form
(Getty Images)
- Jacksonville Jaguars at Buffalo Bills Preview & Picks
- Head To Head
- Jacksonville Jaguars Form
- Buffalo Bills Form
Jacksonville Jaguars at Buffalo Bills Preview & Picks
Jacksonville Jaguars at Buffalo Bills Preview & Picks
Buffalo are tipped to cover as they win this Monday night matchup.
The Bills are starting to erase any preseason concerns about the offense and this defense is capable for forcing Trevor Lawrence into costly mistakes.
- Buffalo Bills are 2-0 so far this season
- Jacksonville Jaguars are 0-2 after two weeks
- The Over has cashed in 6 of Buffalo's last 7 games
- The Over has hit in 4 of the last 5 meetings in Buffalo
Head To Head
- Jacksonville Jaguars lead the all-time series 10-9
- Jacksonville Jaguars won 25-20 when the two teams last met in October 2023
Jacksonville Jaguars Form
Jacksonville entered the 2024 campaign with their sights set on a trip to the playoffs after a disappointing end to last season.
The Jaguars dropped a couple of games early on, but hit a hot streak between early October and late November as they won seven times in an eight-game spell.
Their form nose-dived after that however, as they lost five of their remaining games to miss out on the postseason.
Jacksonville's losing run has now reached seven consecutive games through the first two weeks of the 2024 season.
The Jaguars dropped a heart-breaker on opening day, losing 20-17 in Miami, before losing 18-13 in the home opener against Cleveland.
Buffalo Bills Form
Buffalo came into the 2024 NFL season looking to bounce back from another disappointing trip to the postseason.
The Bills once again made that playoffs in 2023, going 11-6 to win the AFC East, and they cruised through Wildcard round thanks to a 31-17 win over Pittsburgh.
They failed to back that up in the Divisional round though, as they once again lost to Patrick Mahomes and the Kansas City Chiefs in the postseason, this time losing 27-24.
Buffalo made a bunch of changes to the roster in the preseason, leading to concerns about the offense, but they have got off to a solid start.
The Bills opened up with a 34-28 victory over Arizona, and then backed that up with a dominant 31-10 victory over division rivals Miami on the road.
Verdict
Buffalo's offense is putting up plenty of points and an opportunistic defense is taking the ball away.
That makes them an appealing bet against a Jags team that has struggled offensively through two games.
Buffalo -5.5
Spread
@-111.11 - 4 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS
Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.
Over 45.5
Total Points
@-111.11 - 2 Units
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS
Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.
See also
- Washington Commanders at Cincinnati Bengals Preview & Picks – Bengals To Break NFL Duck In Week 3 Finale
- Washington Commanders at Cincinnati Bengals - Get Double Winnings If Your Team Wins & A Selected Player Hits Target
- Jacksonville Jaguars at Buffalo Bills - Get Double Winnings If Your Team Wins & A Selected Player Hits Target
- Baltimore Ravens at Dallas Cowboys Preview & Picks – Cowboys To Rebound With NFL Win
- Philadelphia Eagles at New Orleans Saints Preview & Picks – Saints To Continued Impressive NFL Form
- Kansas City Chiefs at Atlanta Falcons Preview & Picks – Chiefs To Cover As They Go 3-0 In NFL
- New England Patriots at New York Jets Preview & Picks – Back-To-Back NFL Wins For Jets
Upcoming Events
11 August 2026
Daniel Merida vs Learner Tien Tennis
Daniel Merida Aguilar vs Learner Tien Betting Picks & Live Stream – Confidence Could Carry Merida Aguilar in Montreal
12 August 2026
Teremoana Teremoana vs DeAndre Savage Boxing
Teremoana Teremoana vs DeAndre Savage Live Stream & Picks – How To Watch Fight Live Online
14 August 2026
BC Lions @ CAL Stampeders NFL
BC Lions at Calgary Stampeders Predictions & Picks – Stampeders To Rebound In CFL
15 August 2026
OTT Redblacks @ WIN Blue Bombers NFL
Ottawa Redblacks at Winnipeg Blue Bombers Predictions & Picks – Bombers To See Off Winless Redblacks In CFL
16 August 2026
Mackenzie Dern vs Gillian Robertson UFC
Mackenzie Dern vs Gillian Robertson Predictions & Picks – Back Dern To Remain Champion At UFC 330
Claressa Shields vs Kaye Scott Boxing
Claressa Shields vs Kaye Scott Live Stream & Picks – How To Watch & Bet On World Title Fight Live Online
Islam Makhachev vs Ian Machado Garry UFC
Islam Makhachev vs Ian Machado Garry Predictions & Picks – Islam To Retain Title At UFC 330
How To Watch UFC 330: Makhachev vs Machado Garry Live Stream
23 August 2026
Rolando Romero vs Teofimo Lopez Boxing
Rolando Romero vs Teofimo Lopez Live Stream – How To Watch World Title Fight Live Online
29 August 2026
04 September 2026
College Football Outright Betting Tips NFL
College Football Predictions & Picks – Miami To Finally End ACC Conference Title Wait
13 September 2026
20 September 2026
Floyd Mayweather Jr vs Manny Pacquiao 2 Boxing
Floyd Mayweather Jr vs Manny Pacquiao 2 Preview & Picks – Mayweather To Repeat 2015 Victory
31 October 2026
31 December 2026
UFC Betting Specials 2026 UFC
UFC Bad Beat Refund Offer – Money Back If Your Fighter Loses In Final Round
UFC Split Decision Insurance - Money Back If Your Pick Loses By Split Decision
UFC Split Decision Breaker – Money Back If Your Fighter Loses Via Split Decision
Ultimate Fighting Jackpot – Win 1 Bitcoin & Share Of $2,000 For Every UFC Card
Poker EventsStarts in
Teremoana Teremoana vs DeAndre Savage
BC Lions @ CAL Stampeders
OTT Redblacks @ WIN Blue Bombers
Claressa Shields vs Kaye Scott
Mackenzie Dern vs Gillian Robertson
Islam Makhachev vs Ian Machado Garry
Rolando Romero vs Teofimo Lopez
Moses Itauma vs Filip Hrgovic
College Football Outright Betting Tips
Ryan Garcia vs Conor Benn
Floyd Mayweather Jr vs Manny Pacquiao 2
2026 MLB Betting Specials
Latest News
-
Back The Over -
NFL OddsSuper Bowl LXI Odds – Seattle Seahawks Favored For Back-To-Back NFL Crowns10 Feb 2026Read More
-
Back SeahawksSeattle Seahawks vs New England Patriots Preview & Picks – Seahawks To Win Super Bowl LX05 Feb 2026Read More
-
Super Bowl TipsSeattle Seahawks vs New England Patriots MVP Preview & Picks – Who Will Be Named Super Bowl LX MVP?05 Feb 2026Read More
-
NFL TipsSeattle Seahawks vs New England Patriots Preview & Picks – Who Will Score 1st Touchdown Of Super Bowl LX?05 Feb 2026Read More
